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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| acs.joc.3c02142.pdf | 543.03 kB | Adobe PDF | 見る/開く |
| タイトル: | Gold(I)-Catalyzed Cascade Cyclization of Alkynyl Indoles for the Stereoselective Construction of the Quaternary Carbon Center of Akuammiline Alkaloids |
| 著者: | Hashimoto, Naoki Taguchi, Junichi Arichi, Norihito    https://orcid.org/0000-0003-3618-4959 (unconfirmed)Inuki, Shinsuke https://orcid.org/0000-0002-7525-1280 (unconfirmed)Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed) |
| 著者名の別形: | 橋本, 直季 田口, 淳一 有地, 法人 井貫, 晋輔 大野, 浩章 |
| キーワード: | Column chromatography Cyclization Lipids Mixtures Organic compounds |
| 発行日: | 15-Dec-2023 |
| 出版者: | American Chemical Society (ACS) |
| 誌名: | The Journal of Organic Chemistry |
| 巻: | 88 |
| 号: | 24 |
| 開始ページ: | 17306 |
| 終了ページ: | 17321 |
| 抄録: | A gold-catalyzed cyclization reaction of alkynyl-indoles has been developed for the stereoselective construction of the quaternary carbon center of fused indolines. This reaction efficiently produces fused indolines via diastereoselective 6-endo-dig cyclization controlled by a bulky TIPS group, followed by nucleophilic attack of the carboxy group on the resulting imine. The lactone moiety of the fused indoline can be reductively cleaved to produce a tricyclic indoline, which could be useful for the synthesis of akuammiline alkaloids. |
| 著作権等: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'The Journal of Organic Chemistry', copyright © 2023 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.3c02142 The full-text file will be made open to the public on December 5, 2024 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| URI: | http://hdl.handle.net/2433/286469 |
| DOI(出版社版): | 10.1021/acs.joc.3c02142 |
| PubMed ID: | 38051730 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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