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DCフィールド | 値 | 言語 |
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dc.contributor.author | Mae, Shin-Ichi | en |
dc.contributor.author | Hattanda, Fumihiko | en |
dc.contributor.author | Morita, Hiroyoshi | en |
dc.contributor.author | Nozaki, Aya | en |
dc.contributor.author | Katagiri, Naoko | en |
dc.contributor.author | Ogawa, Hanako | en |
dc.contributor.author | Teranaka, Kaori | en |
dc.contributor.author | Nishimura, Yu | en |
dc.contributor.author | Kudoh, Aoi | en |
dc.contributor.author | Yamanaka, Sanae | en |
dc.contributor.author | Matsuse, Kyoko | en |
dc.contributor.author | Ryosaka, Makoto | en |
dc.contributor.author | Watanabe, Akira | en |
dc.contributor.author | Soga, Tomoyoshi | en |
dc.contributor.author | Nishio, Saori | en |
dc.contributor.author | Osafune, Kenji | en |
dc.contributor.alternative | 前, 伸一 | ja |
dc.contributor.alternative | 八反田, 文彦 | ja |
dc.contributor.alternative | 盛田, 大義 | ja |
dc.contributor.alternative | 野崎, 彩 | ja |
dc.contributor.alternative | 片桐, 直子 | ja |
dc.contributor.alternative | 寺中, 香 | ja |
dc.contributor.alternative | 西村, 優 | ja |
dc.contributor.alternative | 工藤, 葵 | ja |
dc.contributor.alternative | 山中, 早苗 | ja |
dc.contributor.alternative | 松瀬, 恭子 | ja |
dc.contributor.alternative | 兩阪, 誠 | ja |
dc.contributor.alternative | 渡辺, 亮 | ja |
dc.contributor.alternative | 曽我, 朋義 | ja |
dc.contributor.alternative | 西尾, 妙織 | ja |
dc.contributor.alternative | 長船, 健二 | ja |
dc.date.accessioned | 2023-12-28T01:18:09Z | - |
dc.date.available | 2023-12-28T01:18:09Z | - |
dc.date.issued | 2023-12-26 | - |
dc.identifier.uri | http://hdl.handle.net/2433/286477 | - |
dc.description | 腎集合管オルガノイドを用いた多発性嚢胞腎モデルの作製 iPS創薬により治療薬候補を発見、治験開始へ. 京都大学プレスリリース. 2023-12-01. | ja |
dc.description | Developing more advanced renal organoids to model polycystic kidney disease. 京都大学プレスリリース. 2023-12-01. | en |
dc.description.abstract | In autosomal dominant polycystic kidney disease (ADPKD), renal cyst lesions predominantly arise from collecting ducts (CDs). However, relevant CD cyst models using human cells are lacking. Although previous reports have generated in vitro renal tubule cyst models from human induced pluripotent stem cells (hiPSCs), therapeutic drug candidates for ADPKD have not been identified. Here, by establishing expansion cultures of hiPSC-derived ureteric bud tip cells, an embryonic precursor that gives rise to CDs, we succeed in advancing the developmental stage of CD organoids and show that all CD organoids derived from PKD1−/− hiPSCs spontaneously develop multiple cysts, clarifying the initiation mechanisms of cystogenesis. Moreover, we identify retinoic acid receptor (RAR) agonists as candidate drugs that suppress in vitro cystogenesis and confirm the therapeutic effects on an ADPKD mouse model in vivo. Therefore, our in vitro CD cyst model contributes to understanding disease mechanisms and drug discovery for ADPKD. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2023 The Authors. | en |
dc.rights | This is an open access article under the CC BY license. | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.subject | human induced pluripotent stem cell | en |
dc.subject | autosomal dominant polycystic kidney disease | en |
dc.subject | ureteric bud | en |
dc.subject | collecting duct | en |
dc.subject | organoid | en |
dc.subject | in vitro model | en |
dc.subject | high-throughput screening | en |
dc.title | Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Cell Reports | en |
dc.identifier.volume | 42 | - |
dc.identifier.issue | 12 | - |
dc.relation.doi | 10.1016/j.celrep.2023.113431 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 113431 | - |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | CyberomiX Co., Ltd. | en |
dc.address | CyberomiX Co., Ltd. | en |
dc.address | CyberomiX Co., Ltd. | en |
dc.address | Medical Innovation Center, Graduate School of Medicine, Kyoto University | en |
dc.address | Institute for Advanced Bioscience, Keio University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.address | CyberomiX Co., Ltd.; Medical Innovation Center, Graduate School of Medicine, Kyoto University | en |
dc.address | Institute for Advanced Bioscience, Keio University | en |
dc.address | Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University | en |
dc.address | Center for iPS Cell Research and Application (CiRA), Kyoto University | en |
dc.identifier.pmid | 38039961 | - |
dc.relation.url | https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/231201-010000.html | - |
dc.relation.url | https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/231201-010000.html | - |
dcterms.accessRights | open access | - |
datacite.awardNumber | 19K08703 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08703/ | - |
dc.identifier.pissn | 2639-1856 | - |
dc.identifier.eissn | 2211-1247 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | ヒトiPS細胞に由来する尿管芽オルガノイドの拡大培養法の開発 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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