ダウンロード数: 86
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
5.0176048.pdf | 1.5 MB | Adobe PDF | 見る/開く |
タイトル: | Metalation and activation of Zn²⁺enzymes via early secretory pathway-resident ZNT proteins |
著者: | Kambe, Taiho ![]() ![]() ![]() Wagatsuma, Takumi |
著者名の別形: | 神戸, 大朋 我妻, 拓実 |
キーワード: | Homeostasis Diseases and conditions Enzymes Biosynthesis Eukaryotic cells Proteins Adenosine |
発行日: | Dec-2023 |
出版者: | AIP Publishing |
誌名: | Biophysics Reviews |
巻: | 4 |
号: | 4 |
論文番号: | 041302 |
抄録: | Zinc (Zn²⁺), an essential trace element, binds to various proteins, including enzymes, transcription factors, channels, and signaling molecules and their receptors, to regulate their activities in a wide range of physiological functions. Zn²⁺ proteome analyses have indicated that approximately 10% of the proteins encoded by the human genome have potential Zn²⁺ binding sites. Zn²⁺binding to the functional site of a protein (for enzymes, the active site) is termed Zn²⁺metalation. In eukaryotic cells, approximately one-third of proteins are targeted to the endoplasmic reticulum; therefore, a considerable number of proteins mature by Zn²⁺metalation in the early secretory pathway compartments. Failure to capture Zn²⁺ in these compartments results in not only the inactivation of enzymes (apo-Zn²⁺ enzymes), but also their elimination via degradation. This process deserves attention because many Zn²⁺ enzymes that mature during the secretory process are associated with disease pathogenesis. However, how Zn²⁺is mobilized via Zn²⁺ transporters, particularly ZNTs, and incorporated in enzymes has not been fully elucidated from the cellular perspective and much less from the biophysical perspective. This review focuses on Zn²⁺ enzymes that are activated by Zn²⁺ metalation via Zn²⁺ transporters during the secretory process. Further, we describe the importance of Zn²⁺ metalation from the physiopathological perspective, helping to reveal the importance of understanding Zn²⁺ enzymes from a biophysical perspective. |
著作権等: | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in (Taiho Kambe, Takumi Wagatsuma; Metalation and activation of Zn2+ enzymes via early secretory pathway-resident ZNT proteins. Biophysics Rev. 1 December 2023; 4 (4): 041302.) and may be found at https://doi.org/10.1063/5.0176048 This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/286478 |
DOI(出版社版): | 10.1063/5.0176048 |
出現コレクション: | 学術雑誌掲載論文等 |
![](/dspace/image/articlelinker.gif)
このリポジトリに保管されているアイテムはすべて著作権により保護されています。