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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s42003-023-05081-w.pdf | 5.41 MB | Adobe PDF | 見る/開く |
| タイトル: | Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5 |
| 著者: | Tamura, Tomokazu Yamasoba, Daichi Oda, Yoshitaka Ito, Jumpei Kamasaki, Tomoko Nao, Naganori Hashimoto, Rina Fujioka, Yoichiro Suzuki, Rigel Wang, Lei Ito, Hayato Kashima, Yukie Kimura, Izumi Kishimoto, Mai Tsuda, Masumi Sawa, Hirofumi Yoshimatsu, Kumiko Yamamoto, Yuki Nagamoto, Tetsuharu Kanamune, Jun Suzuki, Yutaka Ohba, Yusuke The Genotype to Phenotype Japan (G2P-Japan) Consortium Yokota, Isao Matsuno, Keita Takayama, Kazuo    https://orcid.org/0000-0002-1132-2457 (unconfirmed)Tanaka, Shinya Sato, Kei Fukuhara, Takasuke |
| 著者名の別形: | 橋本, 里菜 高山, 和雄 |
| キーワード: | Pathogens SARS-CoV-2 Virology |
| 発行日: | 24-Jul-2023 |
| 出版者: | Springer Nature |
| 誌名: | Communications Biology |
| 巻: | 6 |
| 論文番号: | 772 |
| 抄録: | The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants. |
| 著作権等: | © The Author(s) 2023 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/286985 |
| DOI(出版社版): | 10.1038/s42003-023-05081-w |
| PubMed ID: | 37488344 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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