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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| s41467-024-45274-3.pdf | 7.5 MB | Adobe PDF | 見る/開く |
| タイトル: | Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant |
| 著者: | Tamura, Tomokazu Irie, Takashi Deguchi, Sayaka Yajima, Hisano Tsuda, Masumi Nasser, Hesham Mizuma, Keita Plianchaisuk, Arnon Suzuki, Saori Uriu, Keiya Begum, Mst Monira Shimizu, Ryo Jonathan, Michael Suzuki, Rigel Kondo, Takashi Ito, Hayato Kamiyama, Akifumi Yoshimatsu, Kumiko Shofa, Maya Hashimoto, Rina Anraku, Yuki Kimura, Kanako Terakado Kita, Shunsuke Sasaki, Jiei Sasaki-Tabata, Kaori Maenaka, Katsumi Nao, Naganori Wang, Lei Oda, Yoshitaka The Genotype to Phenotype Japan (G2P-Japan) Consortium Ikeda, Terumasa Saito, Akatsuki Matsuno, Keita Ito, Jumpei Tanaka, Shinya Sato, Kei Hashiguchi, Takao    https://orcid.org/0000-0001-7578-7571 (unconfirmed)Takayama, Kazuo https://orcid.org/0000-0002-1132-2457 (unconfirmed)Fukuhara, Takasuke |
| 著者名の別形: | 田村, 友和 入江, 崇 出口, 清香 矢島, 久乃 津田, 真寿美 水間, 奎太 鈴木, 紗織 瓜生, 慧也 清水, 凌 鈴木, 理滋 近藤, 隆 伊藤, 駿 上山, 晟史 吉松, 組子 橋本, 里菜 安楽, 佑樹 木村, 香菜子 喜多, 俊介 佐々木, 慈英 田畑, 香織 前仲, 勝実 直, 亨則 王, 磊 小田, 義崇 池田, 輝政 齊藤, 暁 松野, 啓太 伊東, 潤平 田中, 伸哉 佐藤, 佳 橋口, 隆生 高山, 和雄 福原, 崇介 |
| キーワード: | Cryoelectron microscopy SARS-CoV-2 Virus–host interactions |
| 発行日: | 8-Feb-2024 |
| 出版者: | Springer Nature |
| 誌名: | Nature Communications |
| 巻: | 15 |
| 論文番号: | 1176 |
| 抄録: | Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5. |
| 記述: | オミクロンXBB.1.5のウイルス学的特性の解明 --新型コロナウイルスの生態の全容解明に貢献すると期待--. 京都大学プレスリリース. 2024-02-16. Combining expertise to characterize the SARS-CoV-2 Omicron XBB.1.5 variant. 京都大学プレスリリース. 2024-02-19. |
| 著作権等: | © The Author(s) 2024 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. |
| URI: | http://hdl.handle.net/2433/287044 |
| DOI(出版社版): | 10.1038/s41467-024-45274-3 |
| PubMed ID: | 38332154 |
| 関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-02-16-1 https://www.cira.kyoto-u.ac.jp/j/pressrelease/news/240219-130000.html https://www.cira.kyoto-u.ac.jp/e/pressrelease/news/240219-130000.html |
| 出現コレクション: | 学術雑誌掲載論文等 |
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