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eid2903.221060.pdf | 2.92 MB | Adobe PDF | 見る/開く |
タイトル: | Clonal Expansion of Multidrug-Resistant <i>Streptococcus dysgalactiae</i> Subspecies <i>equisimilis</i> Causing Bacteremia, Japan, 2005–2021 |
著者: | Shinohara, Koh Murase, Kazunori ![]() ![]() Tsuchido, Yasuhiro ![]() ![]() ![]() Noguchi, Taro ![]() ![]() Yukawa, Satomi Yamamoto, Masaki ![]() ![]() Matsumura, Yasufumi ![]() ![]() ![]() Nakagawa, Ichiro ![]() ![]() ![]() Nagao, Miki ![]() ![]() ![]() |
著者名の別形: | 篠原, 浩 村瀬, 一典 土戸, 康弘 野口, 太郎 湯川, 理己 山本, 正樹 松村, 康史 中川, 一路 長尾, 美紀 |
発行日: | Mar-2023 |
出版者: | Centers for Disease Control and Prevention (CDC) |
誌名: | Emerging Infectious Diseases |
巻: | 29 |
号: | 3 |
開始ページ: | 528 |
終了ページ: | 539 |
抄録: | Incidence of Streptococcus dysgalactiae subspecies equisimilis (SDSE) bacteremia is increasing in the Kyoto-Shiga region of Japan. We retrospectively analyzed clinical features of SDSE bacteremia and conducted comparative genomic analyses of isolates collected from 146 bacteremia episodes among 133 patients during 2005-2021. Of those patients, 7.7% required vasopressor support, and 7.0% died while in the hospital. The prevalence of isolates resistant to erythromycin, minocycline, and clindamycin increased from 8.6% during 2005-2017 to 21.6% during 2018-2021. Our genomic analysis demonstrated that sequence type 525 and clonal complex 25 were predominant in SDSE isolates collected during 2018-2021. In addition, those isolates had acquired 2 antimicrobial-resistance genes, ermB and tetM, via Tn916-like integrative and conjugative elements (ICEs). Phylogenetic analysis revealed clonal distribution of Tn916-like ICEs in SDSE isolates. Our findings suggest that Tn916-like ICEs contributed to the emergence and recent increase of multidrug-resistant SDSE bacteremia in this region of Japan. |
著作権等: | Public Domain |
URI: | http://hdl.handle.net/2433/287144 |
DOI(出版社版): | 10.3201/eid2903.221060 |
PubMed ID: | 36823027 |
出現コレクション: | 学術雑誌掲載論文等 |
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