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タイトル: | Bisphosphonate use is associated with a decreased joint narrowing rate in the non-arthritic hip |
著者: | Kawai, Toshiyuki Nishitani, Kohei https://orcid.org/0000-0002-8327-3826 (unconfirmed) Okuzu, Yaichiro Goto, Koji Kuroda, Yutaka https://orcid.org/0000-0003-0746-0280 (unconfirmed) Kuriyama, Shinichi Nakamura, Shinichiro Matsuda, Shuichi |
著者名の別形: | 河井, 利之 西谷, 江平 奥津, 弥一郎 後藤, 公志 黒田, 隆 栗山, 新一 中村, 伸一郎 松田, 秀一 |
キーワード: | Hip osteoarthritis Bisphosphonate Osteoporosis Joint space narrowing Knee arthroplasty Joint cartilage bisphosphonates arthritis hips hips knee arthroplasties joint space narrowing radiographs Osteoarthritis (OA) joint degeneration propensity score matching rheumatoid arthritis |
発行日: | Nov-2022 |
出版者: | British Editorial Society of Bone & Joint Surgery |
誌名: | Bone & Joint Research |
巻: | 11 |
号: | 11 |
開始ページ: | 826 |
終了ページ: | 834 |
抄録: | AIMS: The preventive effects of bisphosphonates on articular cartilage in non-arthritic joints are unclear. This study aimed to investigate the effects of oral bisphosphonates on the rate of joint space narrowing in the non-arthritic hip. METHODS: We retrospectively reviewed standing whole-leg radiographs from patients who underwent knee arthroplasties from 2012 to 2020 at our institute. Patients with previous hip surgery, Kellgren-Lawrence grade ≥ II hip osteoarthritis, hip dysplasia, or rheumatoid arthritis were excluded. The rate of hip joint space narrowing was measured in 398 patients (796 hips), and the effects of the use of bisphosphonates were examined using the multivariate regression model and the propensity score matching (1:2) model. RESULTS: A total of 45 of 398 (11.3%) eligible patients were taking an oral bisphosphonate at the time of knee surgery, with a mean age of 75.8 years (SD 6.2) in bisphosphonate users and 75.7 years (SD 6.8) in non-users. The mean joint space narrowing rate was 0.04 mm/year (SD 0.11) in bisphosphonate users and 0.12 mm/year (SD 0.25) in non-users (p < 0.001). In the multivariate model, age (standardized coefficient = 0.0867, p = 0.016) and the use of a bisphosphonate (standardized coefficient = -0.182, p < 0.001) were associated with the joint space narrowing rate. After successfully matching 43 bisphosphonate users and 86 non-users, the joint narrowing rate was smaller in bisphosphonate users (p < 0.001). CONCLUSION: The use of bisphosphonates is associated with decreased joint degeneration in non-arthritic hips after knee arthroplasty. Bisphosphonates slow joint degeneration, thus maintaining the thickness of joint cartilage in the normal joint or during the early phase of osteoarthritis.Cite this article: Bone Joint Res 2022;11(11):826-834. |
著作権等: | © 2022 Author(s) et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/287447 |
DOI(出版社版): | 10.1302/2046-3758.1111.BJR-2022-0155.R1 |
PubMed ID: | 36384277 |
出現コレクション: | 学術雑誌掲載論文等 |
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