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DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Budair, Fatimah Mohammad | en |
dc.contributor.author | Nomura, Takashi | en |
dc.contributor.author | Hirata, Masahiro | en |
dc.contributor.author | Kabashima, Kenji | en |
dc.contributor.alternative | 野村, 尚史 | ja |
dc.contributor.alternative | 平田, 勝啓 | ja |
dc.contributor.alternative | 椛島, 健治 | ja |
dc.date.accessioned | 2024-03-25T09:04:37Z | - |
dc.date.available | 2024-03-25T09:04:37Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.uri | http://hdl.handle.net/2433/287463 | - |
dc.description.abstract | T-cell recruitment to skin tissues is essential for inflammation in different cutaneous diseases; however, the mechanisms by which these T cells access the skin remain unclear. High endothelial venules expressing peripheral node address in (PNAd), an L-selectin ligand, are located in secondary lymphoid organs and are responsible for increasing T-cell influx into the lymphoid tissues. They are also found in non-lymphoid tissues during inflammation. However, their presence in different common inflammatory cutaneous diseases and their correlation with T-cell infiltration remains unclear. Herein, we explored the mechanisms underlying the access of T cells to the skin by investigating the presence of PNAd-expressing vessels in different cutaneous diseases, and its correlation with T cells presence. Skin sections of 43 patients with different diseases were subjected to immunohistochemical and immunofluorescence staining to examine the presence of PNAd-expressing vessels in the dermis. The correlation of the percentage of these vessels in the dermis of these patients with the severity/grade of CD3+ T-cell infiltration was assessed. PNAd-expressing vessels were commonly found in the skin of patients with different inflammatory diseases. A high percentage of these vessels in the dermis was associated with increased severity of CD3+ T-cell infiltration (P < 0.05). Additionally, CD3+ T cells were found both around the PNAd-expressing vessels and within the vessel lumen. PNAd-expressing vessels in cutaneous inflammatory diseases, characterized by CD3+ T-cell infiltration, could be a crucial entry point for T cells into the skin. Thus, selective targeting of these vessels could be beneficial in cutaneous inflammatory disease treatment. | en |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press (OUP) | en |
dc.rights | This is a pre-copyedited, author-produced version of an article accepted for publication in [Clinical and Experimental Immunology] following peer review. The version of record [Fatimah Mohammad Budair, Takashi Nomura, Masahiro Hirata, Kenji Kabashima, PNAd-expressing vessels characterize the dermis of CD3+ T-cell-mediated cutaneous diseases, Clinical and Experimental Immunology, Volume 216, Issue 1, April 2024, Pages 80–88] is available online at: https://doi.org/10.1093/cei/uxae003. | en |
dc.rights | The full-text file will be made open to the public on 16 January 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. | en |
dc.rights | This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | en |
dc.subject | inflammation | en |
dc.subject | CD3 | en |
dc.subject | cutaneous | en |
dc.subject | T cells | en |
dc.subject | inflammation | en |
dc.title | PNAd-expressing vessels characterize the dermis of CD3+ T cell-mediated cutaneous diseases | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Clinical and Experimental Immunology | en |
dc.identifier.volume | 216 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 80 | - |
dc.identifier.epage | 88 | - |
dc.relation.doi | 10.1093/cei/uxae003 | - |
dc.textversion | author | - |
dc.identifier.pmid | 38227774 | - |
dcterms.accessRights | embargoed access | - |
datacite.date.available | 2025-01-16 | - |
datacite.awardNumber | 20K08649 | - |
datacite.awardNumber.uri | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08649/ | - |
dc.identifier.pissn | 0009-9104 | - |
dc.identifier.eissn | 1365-2249 | - |
jpcoar.funderName | 日本学術振興会 | ja |
jpcoar.awardTitle | 肥厚性皮膚骨膜症(PDP)患者由来iPS細胞を用いたPDP新規治療薬の開発 | ja |
出現コレクション: | 学術雑誌掲載論文等 |
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