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タイトル: | Feasibility of Narrow-Spectrum Antimicrobial Agents for Post-Operative Intra-Abdominal Infections After Gastrectomy |
著者: | Goto, Kentaro Hata, Hiroaki Degawa, Kanako Nakanishi, Yasutaka Obama, Kazutaka |
著者名の別形: | 後藤, 健太郎 畑, 啓昭 出川, 佳奈子 中西, 保貴 小濵, 和貴 |
キーワード: | antimicrobial stewardship program broad-spectrum antibiotic cefmetazole complication post-gastrectomy surgical site infection |
発行日: | Sep-2024 |
出版者: | Mary Ann Liebert Inc |
誌名: | Surgical Infections |
巻: | 25 |
号: | 7 |
開始ページ: | 492 |
終了ページ: | 498 |
抄録: | Introduction: Recently, antimicrobial resistance has received considerable attention. Broad-spectrum antimicrobial agents are recommended as the initial therapy for post-operative intra-abdominal infections. However, at our institution, we have adopted a tactic of initially treating post-operative intra-abdominal complications with relatively narrow-spectrum antimicrobial agents, such as second-generation cephalosporins. In the present study, we aimed to retrospectively analyze the use of antimicrobial agents and the resulting treatment outcomes in patients with intra-abdominal complications after gastrectomy at our facility. Methods: We conducted a retrospective observational study of patients treated with antibiotic agents for intra-abdominal infectious complications after gastrectomy between 2011 and 2021. We determined the proportion of "initial treatment failures" associated with the initial administration of antibiotic agents for post-operative intra-abdominal complications. Results: Post-operative intra-abdominal infections were observed in 29 patients. Broad-spectrum antimicrobial agents were not administered. We successfully treated 19 patients. Initial treatment failure was observed in 10 patients, of whom five experienced failure due to bacterial resistance to the initial antimicrobial agent. All 10 patients who experienced initial treatment failure were discharged after drainage procedures or other treatments. There were no deaths due to post-operative complications. Cefmetazole was used as the initial antimicrobial agent in 27 of the 29 patients. Conclusions: Considering that all patients with post-gastrectomy intra-abdominal infections were successfully treated using relatively narrow-spectrum antimicrobial agents, and initial treatment failure due to antimicrobial-resistant pathogens was 17.2%, the use of narrow-range antimicrobial agents for intra-abdominal infections after gastrectomy can be deemed appropriate. |
著作権等: | This is the accepted version of the following article: [Goto Kentaro, Hata Hiroaki, Degawa Kanako, Nakanishi Yasutaka, Obama Kazutaka. Feasibility of Narrow-Spectrum Antimicrobial Agents for Post-Operative Intra-Abdominal Infections After Gastrectomy. Surgical Infections 2024 25:7, 492-498.], which has now been formally published in final form at Surgical Infections at https://doi.org/10.1089/sur.2024.020 This original submission version of the article may be used for non-commercial purposes in accordance with the Mary Ann Liebert, Inc., publishers’ self-archiving terms and conditions. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/289509 |
DOI(出版社版): | 10.1089/sur.2024.020 |
PubMed ID: | 38973700 |
出現コレクション: | 学術雑誌掲載論文等 |
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