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タイトル: Avacopan's potential to decrease MPO-ANCA titres concurrent with ameliorated activity in ANCA-associated vasculitis
著者: Taniguchi, Tomoki
Hiwa, Ryosuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-6968-5712 (unconfirmed)
Shoji, Mikihito
Yamaguchi, Eriho
Shirakashi, Mirei  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1135-0463 (unconfirmed)
Onizawa, Hideo
Tsuji, Hideaki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-2521-246X (unconfirmed)
Kitagori, Koji  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-8056-8648 (unconfirmed)
Nakashima, Ran
Akizuki, Shuji  kyouindb  KAKEN_id
Onishi, Akira  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3120-1273 (unconfirmed)
Yoshifuji, Hajime  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7082-4900 (unconfirmed)
Tanaka, Masao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8942-2933 (unconfirmed)
Morinobu, Akio  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-4672-638X (unconfirmed)
著者名の別形: 谷口, 智基
日和, 良介
小路, 幹人
山口, 恵利帆
白柏, 魅怜
鬼澤, 秀夫
辻, 英輝
北郡, 宏次
中嶋, 蘭
秋月, 修治
大西, 輝
吉藤, 元
田中, 真生
森信, 暁雄
キーワード: Microscopic polyangiitis (MPA)
myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)
avacopan
発行日: Jun-2024
出版者: Oxford University Press (OUP)
誌名: Modern Rheumatology Case Reports
巻: 8
号: 2
開始ページ: 314
終了ページ: 317
抄録: Avacopan, an orally administered C5a receptor antagonist, is effective in microscopic polyangiitis via the inhibition of neutrophil priming induced by C5a. However, the exact effect of avacopan on the production of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is yet to be clearly established. This report presents a microscopic polyangiitis patient without major organ damage where high levels of MPO-ANCA persisted with high-dose steroid therapy and azathioprine, but the addition of avacopan led to a reduction in MPO-ANCA titres. The present case implies that avacopan-mediated inhibition of C5a may lead to a reduction in MPO-ANCA levels, thereby potentially ameliorating the pathophysiology of ANCA-associated vasculitis. Nevertheless, the impact of avacopan on MPO-ANCA production cannot be asserted solely based on this report; therefore, further examination is necessary through subgroup analysis using data from larger-scale studies.
著作権等: © Japan College of Rheumatology 2024. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/290244
DOI(出版社版): 10.1093/mrcr/rxae016
PubMed ID: 38564324
出現コレクション:学術雑誌掲載論文等

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