このアイテムのアクセス数: 49

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
s12931-024-03032-5.pdf2.49 MBAdobe PDF見る/開く
タイトル: Computed tomography morphological assessments of central airways in interstitial lung abnormalities and idiopathic pulmonary fibrosis
著者: Maetani, Tomoki
Tanabe, Naoya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7481-0212 (unconfirmed)
Tanizawa, Kiminobu
Sakamoto, Ryo  kyouindb  KAKEN_id
Shiraishi, Yusuke
Hayashi, Yusuke
Uyama, Michihiro
Matsunashi, Atsushi
Sato, Susumu
Suzuki, Katsuhiro
Masuda, Izuru
Fukui, Motonari
Kaji, Shizuo
Handa, Tomohiro
Hirai, Toyohiro
著者名の別形: 前谷, 知毅
田辺, 直也
谷澤, 公伸
坂本, 亮
白石, 祐介
林, 優介
宇山, 倫弘
松梨, 敦史
佐藤, 晋
半田, 知宏
平井, 豊博
キーワード: Idiopathic pulmonary fibrosis
Interstitial lung abnormality
Computed tomography
Imaging
Central airway morphology
Airway disease
Tortuosity
Curvature
Traction bronchiectasis
発行日: 10-Nov-2024
出版者: Springer Nature
BMC
誌名: Respiratory Research
巻: 25
論文番号: 404
抄録: Background: Little is known about whether central airway morphological changes beyond traction bronchiectasis develop and affect clinical outcomes in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to compare central airway structure comprehensively between patients with IPF, subjects with interstitial lung abnormality (ILA), and those without ILA (control) using computed tomography (CT). We further examined the prognostic impact of IPF-specific CT airway parameters in patients with IPF. Methods: This retrospective study included male patients with IPF, and male health checkup subjects divided into those with ILA and control based on lung cancer screening CT. Using an artificial intelligence-based segmentation technique, the extent of fibrotic regions in the lung was quantified. After airway tree segmentation, CT parameters for central airway morphology, including the lumen area of the extrapulmonary airways ([extra]LA), wall and lumen area of the segmental/subsegmental intrapulmonary airways ([intra]WA and [intra]LA), tracheal distortion (tortuosity and curvature) and bifurcation angle of the main carina, were calculated. Results: There were 106 patients with IPF, 53 subjects with ILA, and 1295 controls. Multivariable models adjusted for age, height and smoking history revealed that [intra]LA and [intra]WA were larger in both ILA and IPF, and that tracheal tortuosity and curvature were higher in IPF, but not in ILA, than in the control, whereas the bifurcation angle did not differ between the 3 groups. According to multivariable Cox proportional hazards models including only patients with IPF, increased [intra]WA was significantly associated with greater mortality (standardized hazard ratio [95% confidence interval] = 1.58 [1.17, 2.14]), independent of the volume of fibrotic regions, normal-appearing regions, or the whole airway tree in the lung. Conclusion: Increased lumen area and wall thickening of the central airways may be involved in the pathogenesis of ILA and IPF, and wall thickening may affect the prognosis of patients with IPF.
著作権等: © The Author(s) 2024.
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
URI: http://hdl.handle.net/2433/290408
DOI(出版社版): 10.1186/s12931-024-03032-5
PubMed ID: 39523300
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このアイテムは次のライセンスが設定されています: クリエイティブ・コモンズ・ライセンス Creative Commons