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j.parkreldis.2024.107134.pdf | 2 MB | Adobe PDF | 見る/開く |
タイトル: | Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease |
著者: | Sakamaki-Tsukita, Haruhi Shima, Atsushi ![]() ![]() ![]() Kambe, Daisuke Furukawa, Koji Nishida, Akira Wada, Ikko Yoshimura, Kenji Sakato, Yusuke Terada, Yuta Yamakado, Hodaka ![]() ![]() Taruno, Yosuke Nakanishi, Etsuro ![]() ![]() Sawamura, Masanori Fushimi, Yasutaka ![]() ![]() ![]() Okada, Tomohisa Nakamoto, Yuji Zaborszky, Laszlo Takahashi, Ryosuke ![]() ![]() ![]() Sawamoto, Nobukatsu ![]() ![]() |
著者名の別形: | 酒巻, 春日 島, 淳 神辺, 大輔 古川, 公嗣 西田, 聖 和田, 一孝 吉村, 賢二 坂戸, 勇介 寺田, 祐太 山門, 穂高 樽野, 陽亮 中西, 悦郎 澤村, 正典 伏見, 育崇 岡田, 知久 中本, 裕士 髙橋, 良輔 澤本, 伸克 |
キーワード: | Nucleus basalis of Meynert Cholinergic Ch4 Cognitive impairment Mediation analysis |
発行日: | Nov-2024 |
出版者: | Elsevier BV |
誌名: | Parkinsonism & Related Disorders |
巻: | 128 |
論文番号: | 107134 |
抄録: | Introduction: Magnetic resonance imaging (MRI)-determined atrophy of the nucleus basalis of Meynert (Ch4) predicts cognitive decline in Parkinson's disease (PD). However, interactions with other brain regions causing the decline remain unclear. This study aimed to describe how MRI-determined Ch4 atrophy leads to cognitive decline in patients with PD. Methods: We evaluated 137 patients with PD and 39 healthy controls using neuropsychological examinations, MRI, and ¹²³I-ioflupane single-photon emission computed tomography. First, we explored brain areas with regional gray matter loss correlated with Ch4 volume reduction using voxel-based morphometry (VBM). We then assessed the correlation between Ch4 volume reduction and cognitive impairments in PD using partial correlation coefficients (rₚₐ[r]). Finally, we examined whether the regional gray matter loss mediated the association between Ch4 volume reduction and cognitive impairments using mediation analysis. Results: Our PD cohort was "advanced-stage enriched." VBM analyses revealed that Ch4 volume loss was correlated with volume reduction in the medial temporal lobe in PD (P < 0.05, family-wise error corrected, >29 voxels). Ch4 volume reduction was significantly correlated with verbal memory deficits in PD when adjusted for age, sex, total brain volume, and ¹²³I-ioflupane uptake in the caudate (rpar = 0.28, P < 0.001). The mediation analysis revealed that the hippocampus mediated the effects of Ch4 volumes on verbal memory (average causal mediation effect = 0.013, 95 % CI = 0.006-0.020, P < 0.001). |
記述: | パーキンソン病の記憶障害への前脳基底部と海馬の関与 --パーキンソン病の認知機能障害の病態解明の鍵 --.京都大学プレスリリース. 2024-09-20. |
著作権等: | © 2024 The Authors.Published by Elsevier Ltd. This is an open access article under the CC BY-NC license. |
URI: | http://hdl.handle.net/2433/290562 |
DOI(出版社版): | 10.1016/j.parkreldis.2024.107134 |
PubMed ID: | 39293154 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-09-20 |
出現コレクション: | 学術雑誌掲載論文等 |

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