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タイトル: Involvement of the basal forebrain and hippocampus in memory deficits in Parkinson's disease
著者: Sakamaki-Tsukita, Haruhi
Shima, Atsushi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-3068-4621 (unconfirmed)
Kambe, Daisuke
Furukawa, Koji
Nishida, Akira
Wada, Ikko
Yoshimura, Kenji
Sakato, Yusuke
Terada, Yuta
Yamakado, Hodaka  kyouindb  KAKEN_id
Taruno, Yosuke
Nakanishi, Etsuro  kyouindb  KAKEN_id
Sawamura, Masanori
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1982-3168 (unconfirmed)
Okada, Tomohisa
Nakamoto, Yuji
Zaborszky, Laszlo
Takahashi, Ryosuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1407-9640 (unconfirmed)
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
著者名の別形: 酒巻, 春日
島, 淳
神辺, 大輔
古川, 公嗣
西田, 聖
和田, 一孝
吉村, 賢二
坂戸, 勇介
寺田, 祐太
山門, 穂高
樽野, 陽亮
中西, 悦郎
澤村, 正典
伏見, 育崇
岡田, 知久
中本, 裕士
髙橋, 良輔
澤本, 伸克
キーワード: Nucleus basalis of Meynert
Cholinergic
Ch4
Cognitive impairment
Mediation analysis
発行日: Nov-2024
出版者: Elsevier BV
誌名: Parkinsonism & Related Disorders
巻: 128
論文番号: 107134
抄録: Introduction: Magnetic resonance imaging (MRI)-determined atrophy of the nucleus basalis of Meynert (Ch4) predicts cognitive decline in Parkinson's disease (PD). However, interactions with other brain regions causing the decline remain unclear. This study aimed to describe how MRI-determined Ch4 atrophy leads to cognitive decline in patients with PD. Methods: We evaluated 137 patients with PD and 39 healthy controls using neuropsychological examinations, MRI, and ¹²³I-ioflupane single-photon emission computed tomography. First, we explored brain areas with regional gray matter loss correlated with Ch4 volume reduction using voxel-based morphometry (VBM). We then assessed the correlation between Ch4 volume reduction and cognitive impairments in PD using partial correlation coefficients (rₚₐ[r]). Finally, we examined whether the regional gray matter loss mediated the association between Ch4 volume reduction and cognitive impairments using mediation analysis. Results: Our PD cohort was "advanced-stage enriched." VBM analyses revealed that Ch4 volume loss was correlated with volume reduction in the medial temporal lobe in PD (P < 0.05, family-wise error corrected, >29 voxels). Ch4 volume reduction was significantly correlated with verbal memory deficits in PD when adjusted for age, sex, total brain volume, and ¹²³I-ioflupane uptake in the caudate (rpar = 0.28, P < 0.001). The mediation analysis revealed that the hippocampus mediated the effects of Ch4 volumes on verbal memory (average causal mediation effect = 0.013, 95 % CI = 0.006-0.020, P < 0.001).
記述: パーキンソン病の記憶障害への前脳基底部と海馬の関与 --パーキンソン病の認知機能障害の病態解明の鍵 --.京都大学プレスリリース. 2024-09-20.
著作権等: © 2024 The Authors.Published by Elsevier Ltd.
This is an open access article under the CC BY-NC license.
URI: http://hdl.handle.net/2433/290562
DOI(出版社版): 10.1016/j.parkreldis.2024.107134
PubMed ID: 39293154
関連リンク: https://www.kyoto-u.ac.jp/ja/research-news/2024-09-20
出現コレクション:学術雑誌掲載論文等

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