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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| acs.orglett.4c04439.pdf | 1.86 MB | Adobe PDF | 見る/開く |
| タイトル: | Photoredox-Catalyzed Site-Selective Intermolecular C(sp³)--H Alkylation of Tetrahydrofurfuryl Alcohol Derivatives |
| 著者: | Abe, Reiji Nagao, Kazunori    https://orcid.org/0000-0003-3141-5279 (unconfirmed)Seki, Tomohiro Hata, Dai Sasaki, Yusuke Ohmiya, Hirohisa https://orcid.org/0000-0002-1374-1137 (unconfirmed) |
| キーワード: | Alcohols Chemical Reactions Functionalization Nucleic Acids Post-translational Modification |
| 発行日: | 24-Jan-2025 |
| 出版者: | American Chemical Society (ACS) |
| 誌名: | Organic Letters |
| 巻: | 27 |
| 号: | 3 |
| 抄録: | 4′-Selective alkylation of nucleosides has been recognized as one of the ideal and straightforward approaches to chemically modified nucleosides, but such a transformation has been scarce and less explored. In this Letter, we combine a visible-light-mediated photoredox catalysis and hydrogen atom transfer (HAT) auxiliary to achieve β-C(sp³)--H alkylation of alcohol on tetrahydrofurfuryl alcohol scaffolds and exploit it for 4′-selective alkylation of nucleosides. The reaction involves an intramolecular 1, 5-HAT process and stereocontrolled Giese addition of the resultant radicals. |
| 著作権等: | This article is licensed under CC-BY 4.0 |
| URI: | http://hdl.handle.net/2433/292219 |
| DOI(出版社版): | 10.1021/acs.orglett.4c04439 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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