Distal C–H functionalization of alkoxyarenes through organic photoredox-catalyzed radical–radical coupling

Abstract

We developed a distal C–H functionalization of electron-rich arenes such as alkoxyarenes using diverse coupling partners through organic photoredox catalysis. Our reaction features radical–radical coupling between a cyclohexadienyl radical and various persistent radicals. A range of functional groups, including sp2 carbon-based groups such as alkoxycarbonyl and pyridyl, as well as heteroatom-containing groups like sulfonyl, and alkyl groups were successfully introduced.