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タイトル: | Tensile Stress on Microtubules Facilitates Dynein-Driven Cargo Transport |
著者: | Nasrin, Syeda Rubaiya Yamashita, Takefumi Ikeguchi, Mitsunori Torisawa, Takayuki Oiwa, Kazuhiro Sada, Kazuki Kakugo, Akira ![]() ![]() ![]() |
著者名の別形: | 角五, 彰 |
キーワード: | Mechanical stress In Vitro Microtubule Cargo transport Dynein |
発行日: | 31-Jul-2024 |
出版者: | American Chemical Society (ACS) |
誌名: | Nano Letters |
巻: | 24 |
号: | 30 |
開始ページ: | 9129 |
終了ページ: | 9136 |
抄録: | Mechanical stress significantly affects the physiological functions of cells, including tissue homeostasis, cytoskeletal alterations, and intracellular transport. As a major cytoskeletal component, microtubules respond to mechanical stimulation by altering their alignment and polymerization dynamics. Previously, we reported that microtubules may modulate cargo transport by one of the microtubule-associated motor proteins, dynein, under compressive mechanical stress. Despite the critical role of tensile stress in many biological functions, how tensile stress on microtubules regulates cargo transport is yet to be unveiled. The present study demonstrates that the low-level tensile stress-induced microtubule deformation facilitates dynein-driven transport. We validate our experimental findings using all-atom molecular dynamics simulation. Our study may provide important implications for developing new therapies for diseases that involve impaired intracellular transport. |
記述: | 微小管の引張が促進するダイニン物質輸送 新たな細胞制御メカニズムの解明. 京都大学プレスリリース. 2024-08-07. |
著作権等: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, Copyright © 2024 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.4c00209. The full-text file will be made open to the public on June 25, 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/293189 |
DOI(出版社版): | 10.1021/acs.nanolett.4c00209 |
PubMed ID: | 38916205 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2024-08-07 |
出現コレクション: | 学術雑誌掲載論文等 |

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