Access count of this item: 14
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| bjh.19372.pdf | 1.01 MB | Adobe PDF | View/Open |
| Title: | First complete remission favours haploidentical haematopoietic stem cell transplantation with post-transplant cyclophosphamide over cord blood transplantation in acute lymphoblastic leukaemia |
| Authors: | Jo, Tomoyasu Ueda, Tomoaki Akahoshi, Yu Kondo, Tadakazu Uchida, Naoyuki Tanaka, Masatsugu Nakamae, Hirohisa Doki, Noriko Ota, Shuichi Sawa, Masashi Ohigashi, Hiroyuki Maruyama, Yumiko Takayama, Nobuyuki Nishida, Tetsuya Hiramoto, Nobuhiro Katayama, Yuta Kanda, Yoshinobu Ichinohe, Tatsuo Atsuta, Yoshiko Arai, Yasuyuki    https://orcid.org/0000-0002-9662-5093 (unconfirmed)The Japanese Society for Transplantation and Cellular Therapy (JSTCT) |
| Author's alias: | 城, 友泰 新井, 康之 |
| Keywords: | acute lymphoblastic leukaemia HLA-haploidentical stem cell transplantation using post-transplant cyclophosphamide umbilical cord blood |
| Issue Date: | May-2024 |
| Publisher: | Wiley |
| Journal title: | British Journal of Haematology |
| Volume: | 204 |
| Issue: | 5 |
| Start page: | 1913 |
| End page: | 1919 |
| Abstract: | To assess the benefits of HLA-haploidentical haematopoietic stem cell transplantation using post-transplant cyclophosphamide (PTCy-haplo) relative to those of umbilical cord blood (UCB) transplantation in acute lymphoblastic leukaemia (ALL), we analysed 1999 patients (PTCy-haplo, 330; UCB, 1669), using the nationwide Japanese registry. PTCy-haplo was associated with a significantly higher relapse rate, but lower non-relapse mortality, which results in overall survival and disease-free survival, comparable to those of UCB. Among patients in CR1, PTCy-haplo showed a significantly higher survival than UCB regardless of the CD34⁺ cell dose. Our findings provide valuable insights into the donor selection algorithm in allogeneic HSCT for adult patients with ALL. |
| Description: | 急性白血病におけるHLA半合致移植と臍帯血移植の比較 ―症例に応じた最適な造血幹細胞移植を目指して―. 京都大学プレスリリース. 2024-03-04. |
| Rights: | © 2024 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| URI: | http://hdl.handle.net/2433/293598 |
| DOI(Published Version): | 10.1111/bjh.19372 |
| PubMed ID: | 38420726 |
| Related Link: | https://www.kyoto-u.ac.jp/ja/research-news/2024-03-04-0 |
| Appears in Collections: | Journal Articles |
This item is licensed under a Creative Commons License
