STUDIES ON ANTITUBERCULOUS FACTORS IN THE LOW MOLECULAR FRACTIONS OF THE SERA OF VARIOUS ANIMAL SPECIES : REPORT I. CRUDE MATERIALS AND THEIR TUBERCULOSTATIC EFFECTS

Abstract

1) The tuberculostatic activity of the low molecular fraction (able to pass through a cellophane membrane) in the serum of various animal species (human, bovine, rabbits, goats, dogs, cats, horses and guinea pigs) was observed. No distinct difference among the various animal species was existed. 2) The antituberculous substances did not possess the inhibitory activity on the growth of Mycobacterium 607 and the effect on the avian strain (Cho-Kyo strain) of tubercle bacilli was indefinite. 3) The substances are soluble in water and in methanol, insoluble in buthanol, ethyl ether, acetone and benzene, and soluble partially in ethanol. 4) The substances are stable against heating at 120℃ for 60 min. and against hydrolysis at 100℃ for 15 hours with 6N HCL. 5) The activity of these substances was not changed by immunization of the rabbit.