<原著>δ-Hydroxy-γ-Oxo-L-Norvaline (HON) の抗結核菌作用に関する研究 : 〔第 3 篇〕HON と諸種抗結核薬との試験管内併用効果並びに相互薬剤間の耐性上昇形式

Abstract

As a sequel to the previous report (Kekken Kiyo, Vol. 12, No. 2, 1967) of fundamental experiment and clinical studies on HON, in vitro studies were undertaken on the bacteriostatic and bactericidal effects of HON when used in combination with some other antituberculosis agents such as SM, PAS, INH, KM, CS, TH, VM, PZA, EB, SOM, SI, DAT, TC, and OQ. The mode of resistance-acquisition by Myc. tuberculosis H37Rv to each of the combined agents; SM, INH, KM and TH was also evaluated by successive transfers to the media containing increasing concentrations of the drug. The results were as follows : 1. No antagonistic effect was demonstrated between HON and the other antituberculosis agents eximaned in both bacteriostatic and bactericidal experiments. A combined bacteriostatic effect was demonstrated between HON and PZA, DAT or PAS, and a combined bactericidal effect was demonstrated between HON and PZA, PAS or SOM. 2. The development of resistance of H37Rv strain to SM or INH was slightly suppressed when these drugs were combined with HON, but not in case of kanamycin.