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タイトル: | APOE Gene e4 Allele Accelerates the Atrophy of the Inferior Temporal Lobe in Alzheimer's Disease (BIOORGANIC CHEMISTRY-Molecular Clinical Chemistry) |
著者: | Tanaka, Seigo Ueda, Kunihiro |
キーワード: | Apolipoprotein E X-ray CT MRI Xe-133 SPECT Hippocampus Amygdala |
発行日: | Mar-1998 |
出版者: | Institute for Chemical Research, Kyoto University |
誌名: | ICR Annual Report |
巻: | 4 |
開始ページ: | 42 |
終了ページ: | 43 |
抄録: | The apolipoprotein E (APOE) gene e4 allele is a genetic risk factor for late-onset familial and sporadic Alzheimer's disease (AD). The change in size of the whole brain or total ventricular system did not differ significantly among APOE genotypes. The patients with e3/e4 or e4/e4 genotype (e4+ group), however, exhibited severe atrophy in the inferior temporal lobe, while those with e3/e3 genotype (e4- group) showed mild atrophy. Regional cerebral blood flow (rCBF) in the cerebral cortex, particularly in the temporal lobe, was lower in the e4+ group than in the e4- group. These results indicate that possession, and thus expression, of the APOE e4 allele preferentially affects the inferior temporal lobe, encompassing the hippocampus and amygdala, in AD patients. |
URI: | http://hdl.handle.net/2433/65147 |
出現コレクション: | Vol.4 (1997) |
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