Clinical efficacy and tolerability of gosha-jinki-gan, Japanese traditional herbal medicine, in females with overactive bladder

Abstract

過活動膀胱の日本人女性に対する牛車腎気丸の安全性, 効果を, 西洋医学的アプローチでプロスペクティブに評価することを目的とした。44例(平均68歳)に牛車腎気丸を8週間投与し, 排尿回数, IPSS, IPSS-QOL, 残尿を評価。昼間排尿回数は有意に減少し, IPSSも有意に低下した。IPSS-QOLによる効果判定では著効, 有効, 不変, 悪化が7, 46, 41, 7%であった。副作用は9%であった。牛車腎気丸は安全で有用な治療オプションの1つとなりうることが期待される。(著者抄録)

The efficacy and tolerability of a single-agent treatment with 7.5 g/day Gosha-jinki-gan in Japanese females with overactive bladder were analyzed objectively with linguistically validated questionnaires. A total of 44 Japanese females diagnosed as having overactive bladder were enrolled. Before and after the treatment, urinary frequency during the daytime and sleep was counted for two days, and the International Prostate Symptom Score index scores and quality of life index scores were examined. The efficacy assessment was done by comparing the quality of life index scores. The total scores of International Prostate Symptom Score, quality of life index scores and urinary frequency during the daytime and sleep were significantly decreased, respectively. Objective evaluation with the quality of life questionnaire yielded a result of excellent in 7%, improved in 46%, unchanged in 41% and worsened in 7%. Adverse reactions were observed in 9%. Gosha-jinki-gan could be a safe and effective potential therapeutic alternative in females with overactive bladder.