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タイトル: | 前立腺肥大症患者に対するナフトピジル75 mg の有効性および安全性に関する検討 |
その他のタイトル: | The Clinical Efficacy and Safety of Naftopidil 75 mg on Benign Prostatic Hyperplasia Patients with Moderate or Severe Urinary Disturbance |
著者: | 辻畑, 正雄 吉村, 一宏 児島, 康行 小田, 昌良 三宅, 修 内田, 欽也 奥山, 明彦 |
著者名の別形: | Tsujihata, Masao Yoshimura, Kazuhiro Kojima, Yasuyuki Oda, Masayoshi Miyake, Osamu Uchida, Kinya Okuyama, Akihiko |
キーワード: | Naftopidil Benign prostatic hyperplasia I-PSS QOL index |
発行日: | Apr-2009 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 55 |
号: | 4 |
開始ページ: | 181 |
終了ページ: | 186 |
抄録: | We investigated the clinical efficacy and safety of administration of naftopidil at 75 mg for clinically benign hyperplasia patients who had moderate or severe urinary disturbance according to guidelines for clinical studies regarding urination disorder. Among patients with benign prostatic hyperplasia who were treated with a a1-adrenoceptor blocker, we administered naftopidil (75 mg/day) for 12 weeks to 85 patients in whom the global severity was evaluated as moderate or severe. This agent significantly reduced the international prostate symptom score (I-PSS) and residual urine volume, and improved the QOL index and maximum urine flow volume in comparison with the baselines. Concerning the global treatment response, a partial response or better was achieved in 83.8% of the patients. Neither blood pressure nor heart rate were changed in patients who continued to receive this therapy. Side effects included orthostatic hypotension (1 patient : discontinuation), dizziness (2 patients : discontinuation, 1 patient : continuation), and palpitation (1 patient : discontinuation). These results suggest that a once-a-day administration of naftopidil at 75 mg safely relieves urination/accumulated urine symptoms in patients with moderate or severe urination disorder related to prostatic hypertrophy. |
著作権等: | 許諾条件により本文は2010-05-01に公開 |
URI: | http://hdl.handle.net/2433/74778 |
PubMed ID: | 19462821 |
出現コレクション: | Vol.55 No.4 |
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