Downloads: 410
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
j.bbmt.2009.04.008.pdf | 720.64 kB | Adobe PDF | View/Open |
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kanda, Junya | en |
dc.contributor.author | Mizumoto, Chisaki | en |
dc.contributor.author | Kawabata, Hiroshi | en |
dc.contributor.author | Ichinohe, Tatsuo | en |
dc.contributor.author | Tsuchida, Hideyuki | en |
dc.contributor.author | Tomosugi, Naohisa | en |
dc.contributor.author | Matsuo, Keitaro | en |
dc.contributor.author | Yamashita, Kouhei | en |
dc.contributor.author | Kondo, Tadakazu | en |
dc.contributor.author | Ishikawa, Takayuki | en |
dc.contributor.author | Uchiyama, Takashi | en |
dc.contributor.alternative | 諫田, 淳也 | ja |
dc.date.accessioned | 2009-07-31T04:08:21Z | - |
dc.date.available | 2009-07-31T04:08:21Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 10838791 | - |
dc.identifier.uri | http://hdl.handle.net/2433/84530 | - |
dc.description.abstract | The association of iron overload with complications of allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested in previous studies. Because hepcidin plays a central role in the regulation of iron homeostasis, we analyzed the association between pretransplant serum hepcidin-25 levels and early infectious complications after allogeneic HSCT. We studied 55 consecutive adult patients with a median age of 47 years (range: 20-64 years) who underwent allogeneic HSCT for hematologic malignancies at our institution. Thirty-two patients had myelogenous malignancies; the remaining 23 had lymphogenous malignancies. The median pretransplant serum hepcidin level of patients in the study was 21.6 ng/mL (range: 1.4-371 ng/mL), which was comparable to that of healthy volunteers (median: 19.1 ng/mL [range: 2.3-37 ng/mL]; n = 17). When cumulative incidences of documented bacterial and cytomegalovirus (CMV) infections at day 100 were compared according to pretransplant hepcidin-25 levels, the incidence of bacterial, but not CMV, infection, was significantly higher in the high-hepcidin group (?50 ng/mL; n = 17) than in the low-hepcidin group (<50 ng/mL; n = 38) (65% [95% confidence interval, 38%-82%] versus 11% [3%-23%]; P < .001). This finding was confirmed by multivariate Cox analysis adjusted for confounders, including pretransplant ferritin and C-reactive protein (CRP) levels. No fungal infection was documented in either group. These results suggest that the pretransplant serum hepcidin-25 level may be a useful marker for predicting the risk of early bacterial complications after allogeneic HSCT. Larger prospective studies are, however, warranted to confirm our findings. | en |
dc.language.iso | eng | - |
dc.publisher | Elsevier | en |
dc.rights | c 2009 American Society for Blood and Marrow Transplantation. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Allogeneic stem cell transplantation | en |
dc.subject | Bacterial infection | en |
dc.subject | Hepcidin | en |
dc.title | Clinical Significance of Serum Hepcidin Levels on Early Infectious Complications in Allogeneic Hematopoietic Stem Cell Transplantation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Biology of Blood and Marrow Transplantation | en |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 956 | - |
dc.identifier.epage | 962 | - |
dc.relation.doi | 10.1016/j.bbmt.2009.04.008 | - |
dc.textversion | author | - |
dc.identifier.pmid | 19589485 | - |
dc.relation.url | http://www.scopus.com/inward/record.url?eid=2-s2.0-67649619559&partnerID=40 | - |
dcterms.accessRights | open access | - |
Appears in Collections: | Journal Articles |

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.