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Title: The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells
Authors: Yokoo, Noritaka
Baba, Shiro  kyouindb  KAKEN_id
Kaichi, Shinji
Niwa, Akira  kyouindb  KAKEN_id
Mima, Takahiro
Doi, Hiraku
Yamanaka, Shinya  kyouindb  KAKEN_id
Nakahata, Tatsutoshi  kyouindb  KAKEN_id
Heike, Toshio  kyouindb  KAKEN_id
Author's alias: 横尾, 憲孝
平家, 俊男
山中, 伸弥
Keywords: Arrhythmia
Drug loading test
Human embryonic stem cell
Human induced pluripotent stem cell
Issue Date: Sep-2009
Publisher: Elsevier
Journal title: Biochemical and Biophysical Research Communications
Volume: 387
Issue: 3
Start page: 482
End page: 488
Abstract: Developing effective drug therapies for arrhythmic diseases is hampered by the fact that the same drug can work well in some individuals but not in others. Human induced pluripotent stem (iPS) cells have been vetted as useful tools for drug screening. However, cardioactive drugs have not been shown to have the same effects on iPS cell-derived human cardiomyocytes as on embryonic stem (ES) cell-derived cardiomyocytes or human cardiomyocytes in a clinical setting. Here we show that current cardioactive drugs affect the beating frequency and contractility of iPS cell-derived cardiomyocytes in much the same way as they do ES cell-derived cardiomyocytes, and the results were compatible with empirical results in the clinic. Thus, human iPS cells could become an attractive tool to investigate the effects of cardioactive drugs at the individual level and to screen for individually tailored drugs against cardiac arrhythmic diseases.
Rights: c 2009 Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.bbrc.2009.07.052
PubMed ID: 19615974
Appears in Collections:Journal Articles

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