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j.bbrc.2009.10.125.pdf | 4.05 MB | Adobe PDF | 見る/開く |
タイトル: | Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid |
著者: | Ikeda, Mika Naitoh, Motoko Kubota, Hiroshi Ishiko, Toshihiro Yoshikawa, Katsuhiro Yamawaki, Satoko Kurokawa, Masako Utani, Atsushi Nakamura, Tomiyuki Nagata, Kazuhiro Suzuki, Shigehiko |
著者名の別形: | 内藤, 素子 |
キーワード: | Chondroitin sulfate DANCE/fibulin-5 Elastic fibers Glycosaminoglycan Keloid Wound healing |
発行日: | 25-Dec-2009 |
出版者: | Elsevier |
誌名: | Biochemical and Biophysical Research Communications |
巻: | 390 |
号: | 4 |
開始ページ: | 1221 |
終了ページ: | 1228 |
抄録: | Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the roles of these matrix components in the pathogenesis of keloid are largely unknown. Here, we show that elastin and DANCE (also known as fibulin-5), a protein required for elastic fiber formation, are not deposited in the extracellular matrix of keloids, due to excess accumulation of chondoitin sulfate (CS), although the expression of elastin and DANCE is not affected. Amount of CS accumulated in the keloid legion was 6.9-fold higher than in normal skin. Fibrillin-1, a scaffold protein for elastic fiber assembly, was abnormally distributed in the keloid matrix. Addition of purified CS to keloid fibroblast culture resulted in abnormal deposition of fibrillin-1, concomitant with significantly decreased accumulation of elastin and DANCE in the extracellular matrix. We propose that CS plays a crucial role in the development of keloid lesions through inhibition of elastic fiber assembly. |
著作権等: | c 2009 Elsevier Inc. All rights reserved. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/88959 |
DOI(出版社版): | 10.1016/j.bbrc.2009.10.125 |
PubMed ID: | 19879246 |
出現コレクション: | 学術雑誌掲載論文等 |
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