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Title: Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling
Authors: Miyake, Ayumi  kyouindb  KAKEN_id
Takahashi, Yohsuke
Miwa, Hiroyuki
Shimada, Akihiko
Konishi, Morichika
Itoh, Nobuyuki  kyouindb  KAKEN_id
Author's alias: 三宅, 歩
Keywords: Antagonist
Brain
Dkk
Mouse
Neucrin
Wnt
Issue Date: Dec-2009
Publisher: Elsevier
Journal title: Biochemical and Biophysical Research Communications
Volume: 390
Issue: 3
Start page: 1051
End page: 1055
Abstract: A gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region. The positions of 10 cysteine residues in the cysteine-rich domain are similar to those of Dickkopfs (Dkks), secreted Wnt antagonists. However, whereas Dkks have two cysteine-rich domains, Neucrin has only one. Neucrin as well as Dkks bound to LDL receptor-related protein 6 and inhibited the stabilization of cytosolic β-catenin, indicating that Neucrin is an antagonist of canonical Wnt signaling. Mouse Neucrin expression was not detected in any major tissues in the adult, but was detected in developing neural tissues, including the brain and spinal cord. The expression pattern of Neucrin is distinct from that of any Dkk. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues.
Rights: c 2009 Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/89636
DOI(Published Version): 10.1016/j.bbrc.2009.10.113
Appears in Collections:Journal Articles

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