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dc.contributor.authorMiyake, Ayumija
dc.contributor.authorTakahashi, Yohsukeja
dc.contributor.authorMiwa, Hiroyukija
dc.contributor.authorShimada, Akihikoja
dc.contributor.authorKonishi, Morichikaja
dc.contributor.authorItoh, Nobuyukija
dc.contributor.alternative三宅, 歩ja
dc.date.accessioned2009-12-24T05:29:50Z-
dc.date.available2009-12-24T05:29:50Z-
dc.date.issued2009-12ja
dc.identifier.issn0006291Xja
dc.identifier.urihttp://hdl.handle.net/2433/89636-
dc.description.abstractA gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region. The positions of 10 cysteine residues in the cysteine-rich domain are similar to those of Dickkopfs (Dkks), secreted Wnt antagonists. However, whereas Dkks have two cysteine-rich domains, Neucrin has only one. Neucrin as well as Dkks bound to LDL receptor-related protein 6 and inhibited the stabilization of cytosolic β-catenin, indicating that Neucrin is an antagonist of canonical Wnt signaling. Mouse Neucrin expression was not detected in any major tissues in the adult, but was detected in developing neural tissues, including the brain and spinal cord. The expression pattern of Neucrin is distinct from that of any Dkk. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues.ja
dc.language.isoengja
dc.publisherElsevierja
dc.rightsc 2009 Elsevier Inc. All rights reserved.ja
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.subjectAntagonistja
dc.subjectBrainja
dc.subjectDkkja
dc.subjectMouseja
dc.subjectNeucrinja
dc.subjectWntja
dc.titleNeucrin is a novel neural-specific secreted antagonist to canonical Wnt signalingja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleBiochemical and Biophysical Research Communicationsja
dc.identifier.volume390ja
dc.identifier.issue3ja
dc.identifier.spage1051ja
dc.identifier.epage1055ja
dc.relation.doi10.1016/j.bbrc.2009.10.113ja
dc.textversionauthorja
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