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Title: Dynamic regulation of Notch signaling in neural progenitor cells
Authors: Kageyama, Ryoichiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5985-1120 (unconfirmed)
Ohtsuka, Toshiyuki  kyouindb  KAKEN_id
Shimojo, Hiromi  kyouindb  KAKEN_id
Imayoshi, Itaru  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-9728-481X (unconfirmed)
Author's alias: 影山, 龍一郎
Issue Date: Dec-2009
Publisher: Elsevier
Journal title: Current Opinion in Cell Biology
Volume: 21
Issue: 6
Start page: 733
End page: 740
Abstract: In the developing nervous system, differentiating neurons express Delta and activate Notch signaling in their neighboring cells. As a result of Notch activation, neuronal differentiation is inhibited in neighboring cells and they remain neural progenitor cells. Thus, differentiation of neurons and maintenance of neural progenitor cells are well balanced owing to Notch signaling. Recent studies revealed that Notch signaling is under the control of more complex and dynamic regulation than previously thought, such as cell cycle dependent activation and oscillating gene expression. We discuss here recent advances in understanding how Notch signaling is regulated in the developing nervous system and what outcome each type of regulation of Notch signaling leads to. We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells.
Rights: c 2009 Elsevier Ltd. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/89648
DOI(Published Version): 10.1016/j.ceb.2009.08.009
Appears in Collections:Journal Articles

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