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ファイル | 記述 | サイズ | フォーマット | |
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j.ceb.2009.08.009.pdf | 800.97 kB | Adobe PDF | 見る/開く |
タイトル: | Dynamic regulation of Notch signaling in neural progenitor cells |
著者: | Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) Ohtsuka, Toshiyuki Shimojo, Hiromi Imayoshi, Itaru https://orcid.org/0000-0001-9728-481X (unconfirmed) |
著者名の別形: | 影山, 龍一郎 |
発行日: | Dec-2009 |
出版者: | Elsevier |
誌名: | Current Opinion in Cell Biology |
巻: | 21 |
号: | 6 |
開始ページ: | 733 |
終了ページ: | 740 |
抄録: | In the developing nervous system, differentiating neurons express Delta and activate Notch signaling in their neighboring cells. As a result of Notch activation, neuronal differentiation is inhibited in neighboring cells and they remain neural progenitor cells. Thus, differentiation of neurons and maintenance of neural progenitor cells are well balanced owing to Notch signaling. Recent studies revealed that Notch signaling is under the control of more complex and dynamic regulation than previously thought, such as cell cycle dependent activation and oscillating gene expression. We discuss here recent advances in understanding how Notch signaling is regulated in the developing nervous system and what outcome each type of regulation of Notch signaling leads to. We highlight the role of Notch signaling in proliferation and differentiation of neural progenitor cells. |
著作権等: | c 2009 Elsevier Ltd. All rights reserved. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/89648 |
DOI(出版社版): | 10.1016/j.ceb.2009.08.009 |
PubMed ID: | 19783418 |
出現コレクション: | 学術雑誌掲載論文等 |
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