男性不妊を契機に診断された精巣Leydig細胞腫の1例

Abstract

A Leydig cell tumor is a rare disease entity occurring in the testis. Occasionally it is considered to berelated to male infertility. We report a case study of a Leydig cell tumor in a single testis presenting as maleinfertility. A 38-year-old male was referred to our hospital because of a tumor in his right testis. He hadundergone left orchiectomy at one year old because of a testicular tumor. During an examination related tothe infertility, ultrasound revealed a 1 cm tumor. Tumor markers were all within normal ranges.Hormonal examination showed that luteinizing hormone (LH) 30.3 mIU/ml (1.5-12.4) and folliclestimulating hormone (FSH) 11.9 mIU/ml (1.7-8.6) were higher than normal limits, but total testosterone(total T) and estradiol (E2) were within normal ranges. Tumor enucleation was first performed, and thentesticular sperm extraction (TESE) was carried out from a macroscopically normal site of the testis.Histopathological diagnosis was a benign Leydig cell tumor surrounded by Leydig cell hyperplasia. For 12months after the operation there has been no recurrence. Although high LH and FSH persisted, total T andE2 were within normal ranges.