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Title: Glucosamine induces autophagy via an mTOR-independent pathway.
Authors: Shintani, Tomoya
Yamazaki, Fumiyoshi
Katoh, Toshihiko  kyouindb  KAKEN_id
Umekawa, Midori
Matahira, Yoshiharu
Hori, Seiji  KAKEN_id
Kakizuka, Akira  kyouindb  KAKEN_id
Totani, Kazuhide
Yamamoto, Kenji
Ashida, Hisashi
Author's alias: 芦田, 久
Keywords: Autophagy
Polyglutamine disease
Issue Date: 22-Jan-2010
Publisher: Elsevier
Journal title: Biochemical and biophysical research communications
Volume: 391
Issue: 4
Start page: 1775
End page: 1779
Abstract: Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 microM to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects.
Rights: © 2010 Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.bbrc.2009.12.154
PubMed ID: 20045674
Appears in Collections:Journal Articles

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