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タイトル: | Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis. |
著者: | Nagatomo, F Gu, N Fujino, H Okiura, T Morimatsu, F Takeda, I Ishihara, Akihiko |
著者名の別形: | 石原, 昭彦 |
キーワード: | C-reactive protein Derivatives of reactive oxygen metabolites Hyperbaric oxygen exposure Rat Reactive oxygen species Type II collagen-induced arthritis |
発行日: | Mar-2010 |
出版者: | Springer Verlag |
誌名: | Clinical and experimental medicine |
巻: | 10 |
号: | 1 |
開始ページ: | 7 |
終了ページ: | 13 |
抄録: | Arthritis was induced in 9-week-old female Dark Agouti rats by injecting type II collagen. Serum levels of the derivatives of reactive oxygen metabolites (dROMs), which are oxidative stress markers, and C-reactive protein (CRP) in arthritic rats that were exposed to a pressure of 1.25 atmospheres absolute and an oxygen concentration of 36% for 3 weeks (arthritis + HBO group) were compared to those of control rats (control group) and arthritic rats that were not exposed to hyperbaric oxygen (arthritis group). The body weights of the arthritis and arthritis + HBO groups were lower than that of the control group, whereas no difference in the body weight was observed between the arthritis and arthritis + HBO groups. The serum levels of dROMs and CRP in the arthritis group were higher than those in the control and arthritis + HBO groups. No difference in the serum level of CRP was observed between the control and arthritis + HBO groups. These results indicate that the conditions of hyperbaric oxygen exposure used in this study are effective for reducing the levels of reactive oxygen species, which are overproduced during arthritis. |
著作権等: | c 2009 Springer-Verlag. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/97894 |
DOI(出版社版): | 10.1007/s10238-009-0064-y |
PubMed ID: | 19779965 |
出現コレクション: | 学術雑誌掲載論文等 |
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