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Title: Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
Authors: Kuwahara, Akiko
Yamamori, Motohiro
Nishiguchi, Kohshi
Okuno, Tatsuya
Chayahara, Naoko
Miki, Ikuya
Tamura, Takao
Inokuma, Tsubasa
Takemoto, Yoshiji  kyouindb  KAKEN_id
Nakamura, Tsutomu
Kataoka, Kazusaburo
Sakaeda, Toshiyuki
Author's alias: 栄田, 敏之
Keywords: 5-fluorouracil
Esophageal squamous cell carcinoma
Plasma concentration
Issue Date: Jun-2009
Publisher: Ivyspring International Publisher
Journal title: International Journal of Medical Sciences
Volume: 6
Issue: 6
Start page: 305
End page: 311
Abstract: Objective: The effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated in Japanese patients with esophageal squamous cell carcinoma, who were treated with a definitive 5-FU/CDDP-based chemoradiotherapy. Methods: Fifty-six patients were enrolled, 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg/m<sup>2</sup>/day for days 1-5 and 8-12, infusion of CDDP or NDP at 40 mg/m<sup>2</sup>/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5 PM on days 3, 10, 38 and45, and at 5 AM on days 4, 11, 39 and 46. Results and conclusions: The circadian rhythm in plasma concentrations of 5-FU observed in the case of CDDP was altered when NDP was used instead. The clinical response can be predicted by monitoring plasma concentrations of 5-FU in the CDDP group, but not in the NDP group.
Rights: ©Ivyspring International Publisher
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