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タイトル: | Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma |
著者: | Kuwahara, Akiko Yamamori, Motohiro Nishiguchi, Kohshi Okuno, Tatsuya Chayahara, Naoko Miki, Ikuya Tamura, Takao Inokuma, Tsubasa Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed) Nakamura, Tsutomu Kataoka, Kazusaburo Sakaeda, Toshiyuki |
著者名の別形: | 栄田, 敏之 |
キーワード: | 5-fluorouracil Chemoradiotherapy Esophageal squamous cell carcinoma Nedaplatin Plasma concentration |
発行日: | Jun-2009 |
出版者: | Ivyspring International Publisher |
誌名: | International Journal of Medical Sciences |
巻: | 6 |
号: | 6 |
開始ページ: | 305 |
終了ページ: | 311 |
抄録: | Objective: The effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated in Japanese patients with esophageal squamous cell carcinoma, who were treated with a definitive 5-FU/CDDP-based chemoradiotherapy. Methods: Fifty-six patients were enrolled, 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg/m<sup>2</sup>/day for days 1-5 and 8-12, infusion of CDDP or NDP at 40 mg/m<sup>2</sup>/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5 PM on days 3, 10, 38 and45, and at 5 AM on days 4, 11, 39 and 46. Results and conclusions: The circadian rhythm in plasma concentrations of 5-FU observed in the case of CDDP was altered when NDP was used instead. The clinical response can be predicted by monitoring plasma concentrations of 5-FU in the CDDP group, but not in the NDP group. |
著作権等: | ©Ivyspring International Publisher |
URI: | http://hdl.handle.net/2433/97922 |
DOI(出版社版): | 10.7150/ijms.6.305 |
PubMed ID: | 19834547 |
関連リンク: | http://www.medsci.org/v06p0305.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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