クロロマイセチンによる結核菌のストマイ耐性阻止に就て

Abstract

SMlOmcg/cc添加結核菌培地に結核菌を継代培養して耐性菌を獲得する際同培地にCM2mcg/cc, 5mcg/cc, 10mcg/cc, を添加する事により継代菌の耐性度の差を比較した.継代結核菌の耐性度はCMにより著しく阻止される.又CMの高濃度である程耐性阻止作用は薯しい・

Authers studies on the inhibition of the resistance of tubercle bacilli to streptomycin (SM) by chroramphenicol (CM). When constant dosis (2 mg/cc, 5 mg/cc, 10 mg/cc) of CM were added to SM (10 mg/cc), the development of SM resistance was delayed or repressed in the tubercle bacilli, comparing to the subcultures in SM alone. There was parallel correlation between dosis of CM and repressive effect to the development of SM resistance in tubercle bacilli.