人体泌尿器腫瘍の家兎眼前房内移植 第2編:本実験

Abstract

Heterogenous cultivation of tumor of human G-U organs in the ocular anterior chamber of grown rabbit to which cortisone eye drop was administered, has been undertaken. Removals of the spleen or the endocrine organs (salivary gland, thyroid, adrenals, testis, or ovary), partial hepatectomy, or administration of various hormones (anterior pituitary, ACTH, gonadotropine, salivary, thyroid, thymus, insuline, cortisone, testosterone, synthetic sexual, progesterone etc.) have been carried cut in these rabbits and their influences on the heterogenous germs have been investigated in order to evaluate the relationship between the tumor originated from the G-U organ and hormones. Generally the influences of the hormones on the cultivated renal and bladder tumors were of less significance, while those to the cultivated testicular and prostatic tumors were of significance. A. Grawitz tumor Administ r ation of extract of the thymus and adrenalectomy inhibited the growth of a germ, while administration of hormones, removal of the endocrine organ, and sex of the rabbits barely influenced on the cultivation. B. Papillary cancer of the bladder Better results of cultiva t i on in the male rabbit was obtained. Removal of the endocrine organ, splenectomy, partial hepatectomy, and administration of hormones influenced on the cultivation only in slight degree. Adrenalectomy inhibited the growth of a germ, while the inhibition was of less significance when extract of the thymus was administered. C. Seminoma a) Original tumor Cultivation o f the tumor in female rabbit was much easier than male rabbit . The influence of castration was less significant. Close relation between hormone and growth of the cultivated tumor was observed. Administration of testosterone markedly inhibited the growth of the cultivated tumor. The same tendency was observed in case of gonadotropine administration and adrenalectomy. b) Metastatic tumor Cultivation of t h e tumor in female rabbit was much easier than male rabbit , Influence 465 of hormone administration was more remarkable than the case of the original tumor. Administration of extract of the thymus, testosterone, gonadoropine markedly inhibited the growth of the cultivated tumor. Thyroid hormone and synthetic sexual hormone accelerated the growth of the cultivated tumor. D. Prostatic cancer a) Origina l tumor Cultivation o f the tumor in female rabbit was not successful, and oophorectomy did not cause better result of cultivation, while orchidectomy slightly inhibited the growth of the cultivated tumor. Testosterone, progesterone, gonadotropine and thyroidectomy accelerated the growth of the cultivated tumor, while thyroid hormone, extract of the thymus, synthetic sexual hormone and adrenalectomy inhibited the growth of the cultivated tumor. b) Metastatic tumor The sexual diff e rence, removal of the endocrine organs and administration of hormone influenced the growth of the cultivated tumor in very slight degree. Gonadotropine slightly accelerated the growth, while adrenalectomy, administration of thyroid hormone and cortisone inhibited the growth. E. Prostatic hypertrophy Cultivation of the hypertrophied prostate was hardly successful as the prostatic cancer, while oophorectomy made the cultivation possible. However, orchidectomy did not influence the cultivation. Administrations of thyroid hormone, anterior pituitary hormone, testosterone, and progesterone, or removal of the salivary gland accelerated the growth of the cultivated tumor. None of the hormones administered inhibited the growth. Thyroidectomy slightly inhibited the growth. Sexual difference, oophorectomy and administration of hormones did not influence the growth of the cultivated myoma type of the hypertrophied prostate, but remarkable acceleration of the growth of the cultivated tumor was observed by administration of synthetic sexual hormone.