男子前部尿道腺癌の1例

Abstract

As compared with malignamt tumors of the other organs, carcinoma of the urethra in male is a rare disease and adenocarcinoma of the anterior urethra in male is still more rarely seen. The present case is a 54 years old man who had a past history of gonococcus urethrit i s at age of 24. He noted himself to have a tumor on the ventral aspect of the urthra on the day before the visit to our clinic. Cystourethrography revealed a slight shade defect in the anterior urethra. Under diagnosises of urethral tumor and prostatic stone, the patient was follwed as an out—patient. In 10 months, the tumor grew to thum—tip size associated with pain on erection and disturbance of urination so that the patient was brought in our hospital, A partial amputation of the penis with ileo—inguinal lymphnode discection was performed followed by irradiation of 6, 000 r Co60 and chemotherapy. No evidence of recurrence is noted during 1 year period after operation. The extirpated specimen showed that the tumor was locating in the urethral spongiosa arising from the navicular fossa extending to proximally at about 1.5 cm width and the urethral mucosa appeared grossly normal. Microscopically the area of tumor showed hollow formation by neoplastic cells, in which contained PAS and mucicarmin well—stained mucoid substances. This case was supposed to have adenocarcinoma originated from the internal u r ethral gland. On this basis the case was the first reported one in Japan. So far two cases of adinocarcinoma originated from the external urethral gland were reported in Japan. Among 10 cases of adenocarcinoma of the anterior urethra in male we could have collected, the neoplasma was originated from the urethral gland in all except only one case in which it was originated from the urethral mucosa. The case reported by Gotzl was described to be metastatic adenocarcinoma, but we thought his case would be primary carcinoma originated from the urethral gland. Also the case reported by Dobos et al. was thought to be originated from heterotopic Littre" glands.