泌尿生殖器疾患患者および健康人における血清S100ao蛋白の検討

Abstract

健康人の血清S100ao蛋白値は203±107 pg/mlであった.しかし, 今回の健康人の対象者数が20歳代男性および60歳代女性では少なく, 且つ1～2症例で異常高値を示したため, 数値のばらつきが大きかった.この年代を除いた30歳代から50歳代における血清S100ao蛋白値を求めると, 男性で207±103 pg/ml女性で176±87 pg/mlであり, やはり男性で高値であった.泌尿生殖器疾患患者の結果では, 加藤らの報告と同様, 腎細胞癌患者および慢性腎不全患者で, 高い陽性率が得られた

We investigated the clinical significance of the serum S100ao protein in patients with urogenital diseases. The serum levels of S100ao protein were measured in 179 patients with urogenital diseases and 180 healthy volunteers. The mean value of S100ao protein in serum from healthy volunteers was 203 +/- 107 pg/ml (Mean +/- SD). Therefore, the cut-off level was set to 524 pg/ml (Mean +/- 3SD). The levels of S100ao protein in serum were significantly higher in men than in women (P less than 0.05). The levels of S100ao protein in serum were significantly high in the patients in their fifties and sixties compared with the other patients (P less than 0.01). When serum levels exceeding the cut-off level were considered to be positive, the percentages of positivity in each disease were as follows: renal cell carcinoma; 38.7%, bladder tumor; 9.1%, prostatic carcinoma; 12.5%, testicular tumor; 0%, benign prostatic hypertrophy; 7.4%, urolithiasis; 7.1% and chronic renal failure; 100%. The levels of S100ao protein in serum were significantly correlated with those of BUN, serum creatinine and endogenous creatinine clearance, respectively. S100ao protein in serum was increased immediately after operation and returned to the normal range within one to two weeks after operation. As described above, the level of S100ao protein in serum was affected by renal function, operative procedures and age. However, the positive rate of S100ao protein was so high in patients with renal cell carcinoma that serum S100ao protein might be a valuable tumor marker in those patients.