カルシウム剤とクエン酸剤の併用投与による尿中蓚酸排泄量の減少

Abstract

対象は蓚酸Caを主成分とする尿路結石患者, 男性27名, 女性12名で, 各々300 mg/日, 250 mg/日以上のCa排泄を過Ca尿症とすると, 男性12名, 女性1名が該当した.Ca, クエン酸併用投与で, 1)尿中蓚酸は有意に減少し, Caは減少傾向, Mg, Pは不要.2)過Ca尿症を呈さない症例では蓚酸減少, Caは増加傾向, Mg, Pは不変.3)過Ca尿症ではCa, 蓚酸減少, 4)長期投与で, 尿中Ca:1例軽度上昇, 2例低下, 1例不変, 尿中蓚酸は2例低下, 1例上昇.5)投薬中止後尿中蓚酸は2週目3例とも上昇した

Three grams of calcium lactate and 3 g of uralyt U were administered to 39 calcium oxalate stone formers. Urinary oxalate level was reduced significantly without raising urinary calcium level by the administration of the two drugs for two weeks. The mechanism of action of these drugs and the diet which might produce a similar effect were discussed.