前立腺癌骨転移の指標としての尿中ハイドロキシプロリンの有用性(1)

Abstract

骨病巣活動群では, HP/Crの日差変動幅が大きいが, 肥大症・骨病巣なし群に比べ有意に高値となった.骨病巣活動群の1日総HP量は他の2群に比し有意に高値となった.骨病巣安定群は, 低値傾向を示したが, 例数が少なく有意差はない

Twenty-four hour urinary hydroxyproline and urinary hydroxyproline creatinine ratio was measured without prior dietary restriction in 24 patients with prostatic cancer and 16 patients with benign prostatic hypertrophy. Both were elevated in patients with prostatic cancer with active bone metastases compared to the values of prostatic cancer without bone metastasis and benign prostatic hypertrophy. In these cases, the values of urinary hydroxyproline creatinine ratio were more reliable. The results show that urinary hydroxyproline creatinine ratio is a very sensitive indicator of active bone metastases of prostatic cancer without dietary restriction.