慢性前立腺炎患者からのUreaplasma urealyticumの分離成績について

Abstract

慢性前立腺炎患者およびprostatodynia患者のEPS(もしくはVB3)からのU. urealyticumの分離を試みた.慢性前立腺炎患者では97例中40例より, prostatodynia患者では30例中6例よりU. urealyticumが分離され, 両者間に有意差(p<0.05)を認めた.U. urealyticumが分離された慢性前立腺炎患者17例について, MINO投与による臨床効果を検討した.17例中16例にU. urealyticumが陰性化し, EPS(もしくはVB3)中の白血球数は, 17例中14例で正常化もしくは白血球数9/hpf以下, かつ白血球のclumpが認められない所見に改善した.自覚症状については, 17例中11例はほぼ消失し, 4例は時々症状を認める程度に軽快した.以上の成績より, 慢性前立腺炎の一部において, U. urealyticumが原因菌となっている可能性が考えられた

Ureaplasma urealyticum has been considered to be a pathogen of nongonococcal urethritis. To elucidate the pathogenicity of this microorganism in chronic prostatitis, U. urealyticum was isolated from patients with chronic prostatitis and prostatodynia. Using the Taylor-Robinson's method, U. urealyticum was detected in expressed prostatic secretion (EPS) or urine voided after prostatic massage (VB3) in 40 (41.2%) out of 97 patients with chronic prostatitis and 6 (20.0%) out of 30 patients with prostatodynia. Seventeen patients with U. urealyticum-positive chronic prostatitis, 13 of whom had failed to respond to the treatment by other antimicrobial agents, were treated with minocycline. In 16 (94.1%) of the 17 patients, U. urealyticum was eradicated and in 14 patients (82.4%), the elevated white blood cell count was markedly lowered in EPS or VB3. U. urealyticum may prove to be an etiological microorganism of chronic prostatitis.