前立腺癌の酵素学的研究 1.抗男性ホルモン療法に伴う前立腺癌患者血清Lactic Dehydrogenase,Alkaline Phosphatase,Leucine Aminopeptidase,Total Acid Phosphatase,Prostatic Acid Phosphatase,Glutamic Pyruvic Transaminase,Glutamic Oxalacetic Transaminase活性およびLactic Dehydrogenase Isoenzymesの変動と予後との関係について

Abstract

Thirteen cases of prostatic cancer were treated by castration a n d diethylstilbestrol diphosphate (Honvan) administration, and their immediate responses were studied through the changes in the total and prostatic serum lactic dehydrogenase, alkaline phosphatase, leucine aminopeptidase, activities of the acid phosphatase as well as in the LDH isoenzymes. The following results were obtained. 1. The serum LDH activity was lowered by anti-androgenic treatment, remarkably in the cases showing therapeutic response. 2. The serum alkaline phosphatase activity gave no difference between the castration and the Honvan group or between the groups with and without the therapeutic response. 3. The serum leucine aminopeptidase activity of the patients without t h erapeutic response was lower than that with response. The cases not responsive to Honvan mostly showed the great amplitude of the increasing activity. 4. The serum total acid phosp h atase showed a remarkable decrease in the cases effectively treated by anti-androgenic therapy. The prostatic acid phosphatase showed the similar changes as total acid phosphatase, thus demonstrating no more specificity than the total one with regard to clinical findings. 5. Many of the cases with high GOT and GPT value before treatment responded well to the anti-androgenic therapy. 6. Castration result e d in an increase of LDH-I in many of the cases with good prognostic findings and an decrease in many with poor prognosis. This finding, however, was not true in Honvan therapy. LDH-II a n d IV did not either definitely change with anti-androgenic treatment nor showed a correlation to the therapeutic effects. LDH-III increased after ca s t ration in many of the cases with poor prognosis. The percentage of LDH-III was also somewhat high in the cases non-resposive to Honvan treatment. LDH-V decreased after castration or Honvan administration but showed n o correlation to prognosis.