非特異性尿路感染症の細菌学的検索(第2報) (付: Gentamicinの尿路感染症への応用)

Abstract

1. Culture and sensitivity test in non-specific urinary tract infection during four years of 1966 to 1969 were summarized and compared with those of preceding four years. 2. As causative organisms, bacilli increased and cocci decreased to only 10 % of them. Of bacilli, E. coli occupied 50 %, being followed by Proteus, Pseudomonas and Klebsiella. Increase of Klebsiella was conspicuous. Of cocci, Staphylococcus was a leading organism whose incidence was same as that of Pseudomonas. 3. Sensitivity test showed excellence of gentamicin and kanamycin for bacilli as well as that of novobiocin, aminobenzyl penicillin and cephaloridine for cocci. For E. coli, gentamicin, kanamycin, cephaloridine and nalidixic acid showed good sensitivity. For Proteus, gentamicin, kanamycin and nalidixic acid were highly sensitive. Pseudomonas showed resistance against most of the drugs except gentamicin. For Klebsiella, gentamicin, kanamycin and cephaloridine were excellent; and for Staphylococcus, cephaloridine, aminobenzyl penicillin and kanamycin were so. lt can be said that kanamycin was still highly sensitive against various microorganisms except Pseudomonas. Gentamicin showed the best sensitivity against all kinds of the organism. On the other hand, aminobenzyl penicillin found resistant organisms more than expected. Evaluation of the sulfa drugs varied depending upon the quantity of inoculated organisms. When the inoculated amount was small, the sensitivity was high. 4. Sixteen chronic urinary tract infections were treated with gentamicin and all the cases responded well. No side effects were proved except for slightly decreased PSP value.