膀胱腫瘍と微量金属にかんする研究

Abstract

The concentration of zinc (Zn), iron (Fe) and copper (Cu) as trace metals in the trace elements, as well as magnesium (Mg) and calcium (Ca), in the excised tumor tissue, serum and urine of the patients with urinary bladder tumor was measured by using atomic absorption spectrophotometer. The results obtained are as follows. 1) The specimens taken from the tumor generally indiacated increase of Zn and Mg content with decrease of Cu content in comparison with those taken from the normal bladder mucosa. Same was found between the tumor tissue and the normal mucosa taken from same individuals. 2) Increase of Fe and Zn content in the papillary tumor was found, while decrease of Cu content was shown in the infiltrative tumor. Papillary carcinoma seemed to show higher content of Zn than the cancer of other histopathological types. 3) No meaningful difference was observed between the metal content and histopathological malignancies, however, decrease of Cu in stage Bl to D and increase of Ca in stage 0 to A were confirmed. 4) Decrease of serum Fe in the patients of bladder tumor was prominent in comparison with healthy subjects and patients who had removal of tumor. 5) The patients of bladder tumor with anemia showed, in general, tendency of decrease of Zn and Fe, and of increase of Cu compared with the patients without anemia. Content of Zn and Fe returned to normal according to improvement of anemia following operations. 6) Decrease of Zn and Fe was shown in the patients bearing tumor with hypoproteinemia, however, nothing was related to A/G ratio. 7) The patients of bladder tumor seemed to excrete more Fe and less Mg into the urine than healthy subjects. 8) Turbid urine sample revealed increase of Fe and Ca, while clear urine sample showed decrease of Mg. 9) After occult blood in the urine of the patients with bladder tumor was examined, the supernatant was used for the study. Increase of Zn and Fe content in the urine with occult blood was demonstrated. Zn content increased when the amount of occult blood in the urine reached a medium degree. Increase of Zn and Ca content was proved when the amount of occult blood in the urine became large.