ACNU膀胱内注入療法

Abstract

ACNU was instilled into the bladder of dogs and patients with bladder tumors. After the instillation, the concentration of ACNU in the serum, the bladder wall and the lymph nodes was measured. On the other hand, bladder instillation therapy with ACNU was performed in patients with bladder tumors, The results were as follows: 1) In dogs, the concentration of ACNU after the instillation was very low in the serum and was enough to inhibit tumor growth in the bladder wall and lymph nodes. 2) In patients with bladder tumor, the concentration of ACNU in the serum after the instillation was higher than that in dogs although the concentration in the bladder wall was similar to that in dogs. 3) In 7 patients with bladder tumor, ACNU bladder instillation therapy resulted in necrosis on the surface of tumors in 2 out of them. Slow but considerable bone marrow depression, however, was noticed in those two patients. 4) Accordingly, ACNU bladder instillation therapy should be done carefully with frequent checking on side effects.