逆行性尿道抵抗に関する実験的研究

Abstract

A neurogenic bladder model due to upper (Th12) and lower (L5) spinal cord injuries was performed in the rabbit. The retrograde urethral restistance (RUR) was measured and changes of RUR by bulbo-cavernosus reflex (BCR) procedure were recorded on RUR curves. The influences of intramuscular injection of bethanechol, bus copan, pherroxybenzamine (POB) and muscalm on RUR and BCR-RUR were observed. 1. RUR was 37.0cmH2O in the normal rabbits (n=20). RUR in the upper spinal lesion group (n=12) was 42.9cmH2O, and it was 25.0cmH2O in the lower spinal lesion group (n=10). But there was no statistic significance between the three groups. 2. After injection of bethanechol, RUR elevated significantly from 25.0cmH2O to 37.0cmH2O in the lower spinal lesion group. 3. After injection of buscopan, RUR decreased from 42.9cmH2O to 33.8cmH2O in the upper spinal lesion group. But in the other groups, there was no significant change. 4. After injection of POB, RUR decreased from 42.9cmH2O to 20.8cmH2O only in the upper spinal lesion group. 5. After injection of muscalm, RUR decreased from 42.9cmH2O to 20.0cmH2O only in the upper spinal lesion group. 6. The results indicate that the influence of muscalm on RUR was most evident and the next was POB. In RUR the effect of alpha-adrenergics was more dominant than parasympathetics. 7. BCR-RUR in the normal rabbits was higher than that in the upper and lower spinal lesion group. After injection of bethanechol and buscopan, BCR-RUR was reduced in the normal rabbits. In the upper spinal lesion group, BCR-RUR was raised by bethanechol, but it was reduced by POB and muscalm. No change was observed by buscopan. All drugs have no influences on BCRRUR in the lower spinal lesion group. From the results of experiments, innervation concerned in RUR and BCR-RUR was discussed.