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ファイル | 記述 | サイズ | フォーマット | |
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j.yexcr.2010.04.023.pdf | 167.37 kB | Adobe PDF | 見る/開く |
タイトル: | Induction of pluripotency by defined factors. |
著者: | Okita, Keisuke https://orcid.org/0000-0001-5806-1090 (unconfirmed) Yamanaka, Shinya |
著者名の別形: | 沖田, 圭介 山中, 伸弥 |
キーワード: | Reprogramming iPS cell Pathology Cell transplantation therapy |
発行日: | 1-Oct-2010 |
出版者: | Elsevier Inc. |
誌名: | Experimental cell research |
巻: | 316 |
号: | 16 |
開始ページ: | 2565 |
終了ページ: | 2570 |
抄録: | Somatic cells can be reprogrammed into pluripotent stem cells by introducing a combination of several transcription factors. The induced pluripotent stem (iPS) cells from a patient's somatic cells could be useful source of cells for drug discovery and cell transplantation therapies. However, most human iPS cells are made by viral vectors, such as retrovirus and lentivirus, which integrate the reprogramming factors into host genomes and may increase the risk of tumor formation. Studies of the mechanisms underlying the reprogramming and establishment of non-integration methods contribute evidence to resolve the safety concerns associated with iPS cells. On the other hand, patient-specific iPS cells have already been established and used for recapitulating disease pathology. |
著作権等: | © 2010 Elsevier Inc This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/130670 |
DOI(出版社版): | 10.1016/j.yexcr.2010.04.023 |
PubMed ID: | 20420827 |
出現コレクション: | 学術雑誌掲載論文等 |
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