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DCフィールド | 値 | 言語 |
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dc.contributor.author | 塚本, 泰司 | ja |
dc.contributor.author | 白井, 尚 | ja |
dc.contributor.author | 酒本, 貞昭 | ja |
dc.contributor.author | 秋山, 昭人 | ja |
dc.contributor.author | 武内, 宏之 | ja |
dc.contributor.author | 矢島, 通孝 | ja |
dc.contributor.author | 寺尾, 工 | ja |
dc.contributor.author | 遠藤, 之洋 | ja |
dc.contributor.alternative | Tsukamoto, Taiji | en |
dc.contributor.alternative | Shirai, Takashi | en |
dc.contributor.alternative | Sakamoto, Sadaaki | en |
dc.contributor.alternative | Akiyama, Akihito | en |
dc.contributor.alternative | Takeuchi, Hiroyuki | en |
dc.contributor.alternative | Yajima, Michitaka | en |
dc.contributor.alternative | Terao, Takumi | en |
dc.contributor.alternative | Endo, Yukihiro | en |
dc.date.accessioned | 2011-01-28T09:23:50Z | - |
dc.date.available | 2011-01-28T09:23:50Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/134660 | - |
dc.description.abstract | We investigated the effects of dutasteride on voiding and storage symptoms by a post-hoc analysis from two randomized, placebo-controlled, parallel-group studies (Japanese phase II study and phase III study) which assessed the efficacy and safety of dutasteride in Japanese men with benign prostatic hyperplasia (BPH). Men aged 50 years and older, with a prostate volume of 30 cc or greater, an International Prostate Symptom Score (IPSS) of 8 or higher and maximal urinary flow rate of 15 ml/sec or lower were randomized to placebo or dutasteride groups. The number of subjects for the placebo and dutasteride groups was respectively 72 and 72 in the phase II study, and 185 and 193 in the phase III study. Questions 1, 3, 5 and 6 of IPSS were related to voiding symptoms, and Questions 2, 4 and 7 were related to storage symptoms. Changes between pre- and post-treatments were evaluated. In the phase II study, dutasteride significantly improved voiding symptoms and numerically improved storage symptoms compared with the placebo at week 24. In the phase III study, dutasteride significantly improved voiding and storage symptoms compared with the placebo after 52 weeks. These consistent results suggest that dutasteride is effective for both voiding and storage symptoms in Japanese men with BPH. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.rights | 許諾条件により本文は2012-01-01に公開 | ja |
dc.subject | Benign prostatic hyperplasia | en |
dc.subject | Dutasteride | en |
dc.subject | Storage symptom | en |
dc.subject | Japanese | en |
dc.subject.ndc | 494.9 | - |
dc.title | 前立腺肥大症男性における排尿症状および蓄尿症状に対するデュタステリドの効果 | ja |
dc.title.alternative | The Effects of Dutasteride on Voiding and Storage Symptoms in Men with Benign Prostatic Hyperplasia | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 56 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 677 | - |
dc.identifier.epage | 682 | - |
dc.textversion | publisher | - |
dc.sortkey | 01 | - |
dc.address | 札幌医科大学泌尿器科学講座 | ja |
dc.address | 医療法人社団敬愛会みどりクリニック | ja |
dc.address | 医療法人恵愛会中村病院泌尿器科 | ja |
dc.address | 医療法人社団三昭会渋谷新南口クリニック | ja |
dc.address | 医療法人社団新ゆり武内クリニック | ja |
dc.address | やじま泌尿器科クリニック | ja |
dc.address | グラクソ・スミスクライン開発本部 | ja |
dc.address | グラクソ・スミスクライン開発本部 | ja |
dc.startdate.bitstreamsavailable | 2012-01-01 | - |
dc.address.alternative | The Department of Urology, Sapporo Medical University School of Medicine | en |
dc.address.alternative | Midori Clinic | en |
dc.address.alternative | The Department of Urology, Nakamura Hospital | en |
dc.address.alternative | Shibuya Shin-Minamiguchi Clinic | en |
dc.address.alternative | Shin-Yuri Takeuchi Clinic | en |
dc.address.alternative | Yajima Urology Clinic | en |
dc.address.alternative | Development and Medical Affairs Division, GlaxoSmithKline | en |
dc.address.alternative | Development and Medical Affairs Division, GlaxoSmithKline | en |
dc.identifier.pmid | 21273805 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.56 No.12 |
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