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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| bjoc.8.169.pdf | 345.22 kB | Adobe PDF | 見る/開く |
| タイトル: | N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters. |
| 著者: | Uno, Takuya Kobayashi, Yusuke   https://orcid.org/0000-0003-3074-7378 (unconfirmed)Takemoto, Yoshiji  https://orcid.org/0000-0003-1375-3821 (unconfirmed) |
| 著者名の別形: | 竹本, 佳司 |
| キーワード: | α-amino-β-keto esters cross-aza-benzoin α-imino ester N-heterocyclic carbenes organocatalysis umpolung reactions |
| 発行日: | 10-Sep-2012 |
| 出版者: | Beilstein-Institut |
| 誌名: | Beilstein journal of organic chemistry |
| 巻: | 8 |
| 開始ページ: | 1499 |
| 終了ページ: | 1504 |
| 抄録: | An efficient catalytic synthesis of α-amino-β-keto esters has been newly developed. Cross-coupling of various aldehydes with α-imino ester, catalyzed by N-heterocyclic carbene, leads chemoselectively to α-amino-β-keto esters in moderate to good yields with high atom efficiency. The reaction mechanism is discussed, and it is proposed that the α-amino-β-keto esters are formed under thermodynamic control. |
| 著作権等: | © 2012 Uno et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) |
| URI: | http://hdl.handle.net/2433/160376 |
| DOI(出版社版): | 10.3762/bjoc.8.169 |
| PubMed ID: | 23019484 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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