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タイトル: | Humans frequently exposed to a range of non-human primate malaria parasite species through the bites of Anopheles dirus mosquitoes in South-central Vietnam |
著者: | Maeno, Yoshimasa Nguyen, Tuyen Quang Culleton, Richard Kawai, Satoru Masuda, Gaku Nakazawa, Shusuke Marchand, Ron P. |
著者名の別形: | 益田, 岳 |
キーワード: | Sporozoites Anopheles dirus Plasmodium vivax Plasmodium falciparum Plasmodium knowlesi Plasmodium cynomolgi Plasmodium coatneyi Plasmodium inui |
発行日: | 16-Jul-2015 |
出版者: | BioMed Central Ltd. |
誌名: | Parasites and Vectors |
巻: | PARV-D-15-00362R1 |
号: | 8 |
論文番号: | 376 |
抄録: | [Background]Recent studies have described natural human infections of the non-human primate parasitesPlasmodium knowlesi and Plasmodium cynomolgi. In Southeast Asia, mosquitoes of theAnopheles leucosphyrus group bite both humans and monkeys in the forest and thus offer a possible route for Plasmodium species to bridge the species barrier. In this study we analysed the species composition of malarial sporozoites infecting the salivary glands ofAnopheles dirus in order to determine their potential role as bridge vectors of Plasmodiumparasites from monkeys to humans. [Methods]Mosquitoes were collected in the forest and forest fringe area of Khanh Phu commune by human-baited landing collection. Anopheles species were determined on the basis of morphologic features. Sporozoite-infected salivary glands were applied to filter paper and dried in an ambient atmosphere, before storage in closed vials at 4–6 °C. Detection and identification of Plasmodium species in salivary glands were carried out by nested-PCR of the small subunit ribosomal RNA gene. [Results]Six species of Plasmodium parasites were detected by PCR, of which P. vivax was the most common, followed by P. knowlesi, P. inui, P. cynomolgi, P. coatneyi and P. falciparum. Twenty-six of the 79 sporozoite infected mosquitoes showed multiple infections, most of which were a combination of P. vivax with one or more of the non-human primatePlasmodium species. [Conclusions]These results suggest that humans overnighting in this forest are frequently inoculated with both human and non-human primate malaria parasites, leading to a situation conducive for the emergence of novel zoonotic malaria. |
著作権等: | © 2015 Maeno et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
URI: | http://hdl.handle.net/2433/214469 |
DOI(出版社版): | 10.1186/s13071-015-0995-y |
PubMed ID: | 26178324 |
出現コレクション: | 学術雑誌掲載論文等 |
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