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dc.contributor.author | Yamamoto, Takayuki | en |
dc.contributor.author | Li, Yongjia | en |
dc.contributor.author | Hanafusa, Yuki | en |
dc.contributor.author | Yeh, Yu Sheng | en |
dc.contributor.author | Maruki-Uchida, Hiroko | en |
dc.contributor.author | Kawakami, Shinpei | en |
dc.contributor.author | Sai, Masahiko | en |
dc.contributor.author | Goto, Tsuyoshi | en |
dc.contributor.author | Ito, Tatsuhiko | en |
dc.contributor.author | Kawada, Teruo | en |
dc.contributor.alternative | 河田, 照雄 | ja |
dc.contributor.alternative | 後藤, 剛 | ja |
dc.date.accessioned | 2017-02-21T04:29:00Z | - |
dc.date.available | 2017-02-21T04:29:00Z | - |
dc.date.issued | 2017-01-06 | - |
dc.identifier.issn | 2048-7177 | - |
dc.identifier.uri | http://hdl.handle.net/2433/218315 | - |
dc.description.abstract | Piceatannol (PIC), a natural analog of resveratrol (RES), is a phytochemical found in passion fruit seeds. To clarify the effects of PIC on obesity-induced inflammation in adipose tissue, we investigated the anti-inflammatory activity of PIC-related compounds (PIC, RES, and metabolites from PIC) in culture models of obese adipose tissue. Lipopolysaccharide (LPS) and conditioned medium from 3T3-L1 adipocytes (3T3-L1-CM) enhanced proinflammatory gene expression and synthesis of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in RAW264.7 macrophages. Although each compound inhibited the mRNA expression of iNOS (inducible NO synthase), TNF-α, and IL-6, PIC potently inhibited them, and 30 μmol/L PIC suppressed the LPS- and 3T3-L1-CM-induced mRNA expression of iNOS (70.4% and 69.2% suppression, respectively), TNF-α (42.6% and 47.0% suppression), and IL-6 (27.3% and 42.1% suppression). PIC also significantly suppressed production of NO (80.3% suppression) and inflammatory cytokines (TNF-α; 33.7% suppression, IL-6; 66.5% suppression). Furthermore, PIC was found to rescue the uncoupling protein 1 mRNA expression induced by isoproterenol in 10T1/2 adipocytes, which was suppressed by LPS-activated macrophages. These results suggest that PIC may attenuate the pathologic inflammation triggered by adipose tissues. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | en |
dc.rights | © 2016 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en |
dc.subject | 3T3-L1 Adipocytes | en |
dc.subject | C3H10T1/2 adipocytes | en |
dc.subject | inflammation | en |
dc.subject | piceatannol | en |
dc.subject | RAW264.7 macrophages | en |
dc.subject | UCP1 | en |
dc.title | Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Food Science and Nutrition | en |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 76 | - |
dc.identifier.epage | 85 | - |
dc.relation.doi | 10.1002/fsn3.366 | - |
dc.textversion | publisher | - |
dc.address | Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University | en |
dc.address | Research Unit for Physiological Chemistry, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University | en |
dc.address.alternative | 農学研究科食品生物科学専攻食品健康科学講座 | ja |
dc.identifier.pmid | 28070318 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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