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タイトル: | Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi (Ebenaceae) |
著者: | Khan, Muhammad Ali Rahman, Md Mahbubur Sardar, Md Nazmul Arman, Md Saiful Islam Islam, Md Badrul Khandakar, Md Jahangir Alam Rashid, Mamunur Sadik, Golam Alam, AHM Khurshid |
キーワード: | Diospyros blancoi Free radicals Polyphenols Antioxidant Cytotoxicity Anticancer |
発行日: | 8-Jun-2015 |
出版者: | Hainan Medical University |
誌名: | Asian Pacific Journal of Tropical Biomedicine |
巻: | 6 |
号: | 5 |
開始ページ: | 410 |
終了ページ: | 417 |
抄録: | Objective: To investigate the comparative effects of Diospyros blancoi (Ebenaceae) leaves (DBL), root bark (DBRB) and stem bark (DBSB) on free radicals and cancer. Methods: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, respectively. Results: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1, 1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed (95.760 ± 0.343)% and (67.460 ± 2.641)% scavenging with IC50 of (3.10 ± 0.17) and (50.00 ± 3.11) μg/mL, respectively. The IC50 values of standard butylated hydroxytoluene and catechin (CA) for 1, 1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were (8.50 ± 0.25) and (75.00 ± 0.14) μg/mL, respectively suggesting that DBSB had a significant (P < 0.05) radical scavenging activity than standards. In lipid peroxidation inhibition assay, the inhibitory activity of the extracts and the standard was in the following order: DBSB > DBRB > CA > DBL. Also, the phenolic [(139.91 ± 3.924) mg gallic acid equivalent/g] and flavonoid contents [(412.00 ± 16.70) mg catechin equivalent/g)] of DBSB were higher than that of other extracts. In addition, the DBSB showed the moderate cytotoxic and anticancer properties. Conclusions: Our results indicate that Diospyros blancoi stem bark had the significant highest antioxidant and free radical scavenging properties as well as moderate anticancer activity. Hence, we assume that the anticancer activity of this plant can be, at least in part, attributed to its content in phenolic compounds as well as its significant free radical scavenging properties. |
著作権等: | © 2016 Hainan Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/218408 |
DOI(出版社版): | 10.1016/j.apjtb.2016.03.004 |
出現コレクション: | 学術雑誌掲載論文等 |
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