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j.neuron.2015.09.030.pdf | 1.71 MB | Adobe PDF | 見る/開く |
タイトル: | Roles of the Lateral Habenula and Anterior Cingulate Cortex in Negative Outcome Monitoring and Behavioral Adjustment in Nonhuman Primates |
著者: | Kawai, Takashi Yamada, Hiroshi Sato, Nobuya Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Matsumoto, Masayuki https://orcid.org/0000-0003-0832-1565 (unconfirmed) |
著者名の別形: | 川合, 隆嗣 山田, 洋 佐藤, 暢哉 髙田, 昌彦 松本, 正幸 |
発行日: | Nov-2015 |
出版者: | Elsevier BV |
誌名: | Neuron |
巻: | 88 |
号: | 4 |
開始ページ: | 792 |
終了ページ: | 804 |
抄録: | Animals monitor the outcome of their choice and adjust subsequent choice behavior using the outcome information. Together with the anterior cingulate cortex (ACC), the lateral habenula (LHb) has recently attracted attention for its crucial role in monitoring negative outcome. To investigate their contributions to subsequent behavioral adjustment, we recorded single-unit activity from the LHb and ACC in monkeys performing a reversal learning task. The monkey was required to shift a previous choice to the alternative if the choice had been repeatedly unrewarded in past trials. We found that ACC neurons stored outcome information from several past trials, whereas LHb neurons detected the ongoing negative outcome with shorter latencies. ACC neurons, but not LHb neurons, signaled a behavioral shift in the next trial. Our findings suggest that, although both the LHb and the ACC represent signals associated with negative outcome, these structures contribute to subsequent behavioral adjustment in different ways. |
記述: | 負の経験から学ぶ脳のメカニズムを発見 --嫌なことを避ける学習のために二つの脳領域が役割を分担--. 京都大学プレスリリース. 2015-10-16. |
著作権等: | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/218582 |
DOI(出版社版): | 10.1016/j.neuron.2015.09.030 |
PubMed ID: | 26481035 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2015-10-16 |
出現コレクション: | 学術雑誌掲載論文等 |
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